The origin of heredity in protocells.

Autor: West T; Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.; Centre for Computation, Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, Gower Street, London WC1E 6BT, UK., Sojo V; Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.; Centre for Computation, Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, Gower Street, London WC1E 6BT, UK.; Systems Biophysics, Faculty of Physics, Ludwig-Maximilian University of Munich, Amalienstr. 54, 80799 Munich, Germany., Pomiankowski A; Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.; Centre for Computation, Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, Gower Street, London WC1E 6BT, UK., Lane N; Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK nick.lane@ucl.ac.uk.; Centre for Computation, Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, Gower Street, London WC1E 6BT, UK.
Jazyk: angličtina
Zdroj: Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2017 Dec 05; Vol. 372 (1735).
DOI: 10.1098/rstb.2016.0419
Abstrakt: Here we develop a computational model that examines one of the first major biological innovations-the origin of heredity in simple protocells. The model assumes that the earliest protocells were autotrophic, producing organic matter from CO 2 and H 2 Carbon fixation was facilitated by geologically sustained proton gradients across fatty acid membranes, via iron-sulfur nanocrystals lodged within the membranes. Thermodynamic models suggest that organics formed this way should include amino acids and fatty acids. We assume that fatty acids partition to the membrane. Some hydrophobic amino acids chelate FeS nanocrystals, producing three positive feedbacks: (i) an increase in catalytic surface area; (ii) partitioning of FeS nanocrystals to the membrane; and (iii) a proton-motive active site for carbon fixing that mimics the enzyme Ech. These positive feedbacks enable the fastest-growing protocells to dominate the early ecosystem through a simple form of heredity. We propose that as new organics are produced inside the protocells, the localized high-energy environment is more likely to form ribonucleotides, linking RNA replication to its ability to drive protocell growth from the beginning. Our novel conceptualization sets out conditions under which protocell heredity and competition could arise, and points to where crucial experimental work is required.This article is part of the themed issue 'Process and pattern in innovations from cells to societies'.
(© 2017 The Authors.)
Databáze: MEDLINE
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