A disposable, flexible skin patch for clinical optical perfusion monitoring at multiple depths.

Autor: Farkas DL; Northeastern University, Boston, MA 02115.; Radiation Monitoring Devices, 44 Hunt Street, Watertown, MA, USA 02472., Kolodziejski NJ; Radiation Monitoring Devices, 44 Hunt Street, Watertown, MA, USA 02472., Stapels CJ; Radiation Monitoring Devices, 44 Hunt Street, Watertown, MA, USA 02472., McAdams DR; Radiation Monitoring Devices, 44 Hunt Street, Watertown, MA, USA 02472., Fernandez DE; Radiation Monitoring Devices, 44 Hunt Street, Watertown, MA, USA 02472., Podolsky MJ; Radiation Monitoring Devices, 44 Hunt Street, Watertown, MA, USA 02472., Christian JF; Radiation Monitoring Devices, 44 Hunt Street, Watertown, MA, USA 02472., Ward BB; Dept. of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109., Vartarian M; Dept. of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109., Feinberg SE; Dept. of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109., Lee SY; Dept. of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109., Parikh U; Dept. of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109., Mycek MA; Dept. of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109., Joyner MJ; Mayo Clinic, 200 First Street, Rochester, MN 55905., Johnson CP; Mayo Clinic, 200 First Street, Rochester, MN 55905., Paradis NA; Department of Emergency Medicine, Dartmouth-Hitchcock Medical, Lebanon, NH 03766.
Jazyk: angličtina
Zdroj: Proceedings of SPIE--the International Society for Optical Engineering [Proc SPIE Int Soc Opt Eng] 2016 Feb; Vol. 9715. Date of Electronic Publication: 2016 Mar 04.
DOI: 10.1117/12.2230988
Abstrakt: Stable, relative localization of source and detection fibers is necessary for clinical implementation of quantitative optical perfusion monitoring methods such as diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS). A flexible and compact device design is presented as a platform for simultaneous monitoring of perfusion at a range of depths, enabled by precise location of optical fibers in a robust and secure adhesive patch. We will discuss preliminary data collected on human subjects in a lower body negative pressure model for hypovolemic shock. These data indicate that this method facilitates simple and stable simultaneous monitoring of perfusion at multiple depths and within multiple physiological compartments.
Databáze: MEDLINE