Serum methotrexate and human chorionic gonadotropin concentrations during five-day chemotherapy for low-risk metastatic gestational trophoblastic neoplasia.
Autor: | Hilgers RD; Department of Obstetrics and Gynecology, University of New Mexico Medical Center, Albuquerque., Standefer JC, Bowling MC, Greeley P |
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Jazyk: | angličtina |
Zdroj: | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 1988 Dec; Vol. 27 (3), pp. 421-5. |
DOI: | 10.1016/0020-7292(88)90124-5 |
Abstrakt: | A recent report of serum methotrexate (MTX) levels measured during treatment of gestational trophoblastic neoplasia (GTN) led us to determine MTX and human chorionic gonadotropin (beta-hCG) levels in a patient with low-risk metastatic GTN with a pulmonary metastasis. Peak MTX concentrations exceeded 10(-6) mol/l considered by many investigators to be within the therapeutic range against many human tumors. Serum beta-hCG levels did not decline during MTX administration; however, after 5 days of MTX a steep dose-response curve was observed which continued during 5 courses of chemotherapy. |
Databáze: | MEDLINE |
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