Brain Capillary Ultrastructure in Idiopathic Normal Pressure Hydrocephalus: Relationship With Static and Pulsatile Intracranial Pressure.

Autor:	Eidsvaag VA; Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway; Faculty of Medicine; and Division of Physiology, Department of Molecular Medicine, GliaLab and Letten Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden; and Department of Neurology, Oslo University Hospital - Rikshospitalet, Oslo, Norway., Hansson HA; Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway; Faculty of Medicine; and Division of Physiology, Department of Molecular Medicine, GliaLab and Letten Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden; and Department of Neurology, Oslo University Hospital - Rikshospitalet, Oslo, Norway., Heuser K; Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway; Faculty of Medicine; and Division of Physiology, Department of Molecular Medicine, GliaLab and Letten Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden; and Department of Neurology, Oslo University Hospital - Rikshospitalet, Oslo, Norway., Nagelhus EA; Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway; Faculty of Medicine; and Division of Physiology, Department of Molecular Medicine, GliaLab and Letten Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden; and Department of Neurology, Oslo University Hospital - Rikshospitalet, Oslo, Norway., Eide PK; Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway; Faculty of Medicine; and Division of Physiology, Department of Molecular Medicine, GliaLab and Letten Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden; and Department of Neurology, Oslo University Hospital - Rikshospitalet, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2017 Dec 01; Vol. 76 (12), pp. 1034-1045.
DOI:	10.1093/jnen/nlx091
Abstrakt:	Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease of unknown cause. We investigated the morphology of capillaries in frontal cortex biopsies from iNPH patients and related the observations to overnight intracranial pressure (ICP) scores. A biopsy (0.9×10 mm) was taken from where the ICP sensor subsequently was inserted. Brain capillaries were investigated by electron microscopy of biopsies from 27 iNPH patients and 10 reference subjects, i.e. patients (not healthy individuals) without cerebrospinal fluid circulation disturbances, in whom normal brain tissue was removed as part of necessary neurosurgical treatment. Degenerating and degenerated pericyte processes were identified in 23/27 (85%) iNPH and 6/10 (60%) of reference specimens. Extensive disintegration of pericyte processes were recognized in 11/27 (41%) iNPH and 1/10 (10%) reference specimens. There were no differences in basement membrane (BM) thickness or pericyte coverage between iNPH and reference subjects. The pulsatile or static ICP scores did neither correlate with the BM thickness nor with pericyte coverage. We found increased prevalence of degenerating pericytes in iNPH while the BM thickness and pericyte coverage did not differ from the reference individuals. Observations in iNPH may to some extent be age-related since the iNPH patients were significantly older than the reference individuals. (© 2017 American Association of Neuropathologists, Inc. All rights reserved.)
Databáze:	MEDLINE
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