| Autor: |
Dorey ES; 1School of Biomedical Sciences,The University of Queensland,Brisbane,QLD,Australia., Cullen CL; 1School of Biomedical Sciences,The University of Queensland,Brisbane,QLD,Australia., Lucia D; 1School of Biomedical Sciences,The University of Queensland,Brisbane,QLD,Australia., Mah KM; 1School of Biomedical Sciences,The University of Queensland,Brisbane,QLD,Australia., Manchadi MR; 1School of Biomedical Sciences,The University of Queensland,Brisbane,QLD,Australia., Muhlhausler BS; 3School of Agriculture, Food and Wine,The University of Adelaide,Adelaide,SA,Australia., Moritz KM; 1School of Biomedical Sciences,The University of Queensland,Brisbane,QLD,Australia. |
| Abstrakt: |
Alcohol consumption around the time of conception is highly prevalent in Western countries. Exposure to ethanol levels during gestation has been associated with altered development of the mesolimbic reward pathway in rats and increased propensity to addiction, however the effect of exposure only around the time of conception is unknown. The current study investigated the effects of periconceptional alcohol exposure (PC:EtOH) on alcohol and palatable food preferences and gene expression in the ventral tegmental area (VTA) and the nucleus accumbens of the adult offspring. Rats were exposed to a liquid diet containing ethanol (EtOH) (12.5% vol/vol) or a control diet from 4 days before mating until 4 days after mating. PC:EtOH had no effect on alcohol preference in either sex. At 15 months of age, however, male PC:EtOH offspring consumed more high-fat food when compared with male control offspring, but this preference was not observed in females. Expression of the dopamine receptor type 1 (Drd1a) was lower in the VTA of male PC:EtOH offspring compared with their control counterparts. There was no effect of PC:EtOH on mRNA expression of the µ-opioid receptor, tyrosine hydroxylase (Th), dopamine receptor type 2 (Drd2) or dopamine active transporter (Slc6a3). These data support the hypothesis that periconceptional alcohol exposure can alter expression of key components of the mesolimbic reward pathway and heighten the preference of offspring for palatable foods and may therefore increase their propensity towards diet-induced obesity. These results highlight the importance of alcohol avoidance when planning a pregnancy. |
