Pilot-Reported Beta-Blockers Identified by Forensic Toxicology Analysis of Postmortem Specimens.

Autor:	Canfield DV; Civil Aerospace Medical Institute, Federal Aviation Administration, Oklahoma City, OK 73125, USA., Dubowski KM; Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA., Whinnery JM; Civil Aerospace Medical Institute, Federal Aviation Administration, Oklahoma City, OK 73125, USA., Forster EM; Civil Aerospace Medical Institute, Federal Aviation Administration, Oklahoma City, OK 73125, USA.
Jazyk:	angličtina
Zdroj:	Journal of analytical toxicology [J Anal Toxicol] 2018 Jan 01; Vol. 42 (1), pp. 1-5.
DOI:	10.1093/jat/bkx076
Abstrakt:	Introduction: This study compared beta-blockers reported by pilots with the medications found by postmortem toxicology analysis of specimens received from fatal aviation accidents between 1999 and 2015. Several studies have compared drugs using the standard approach: Compare the drug found by toxicology analysis with the drug reported by the pilot. This study uniquely examined first the pilot-reported medication and then compared it to that detected by toxicology analysis. This study will serve two purposes: (i) to determine the capability of a toxicology laboratory to detect reported medications, and (ii) to identify pilots with medications below detectable limits. Method: All information required for this study was extracted from the Toxicology Data Base system and was searched using ToxFlo or SQL Server Management Studio. The following information was collected and analyzed: pilot-reported trade and/or generic drug, date specimens received, time of accident, type of aviation operations (CFR), state, pilot level, age, class of medical, specimen type, specimen concentration, dose reported, frequency reported associated with the accident, quantity reported, National Transportation Safety Board (NTSB) accident event number, and all NTSB reports. Results: There were 319 pilots that either reported taking a beta-blocker or were found to be taking a beta-blocker by postmortem toxicology analysis. Discussion: Time of death, therapeutic concentration and specimen type were found to be factors in the ability of the laboratory to detect beta-blockers. Beta-blockers taken by pilots will, in most cases, be found by a competent postmortem forensic toxicology laboratory at therapeutic concentrations. The dose taken by the pilot was not found to be a factor in the ability of the laboratory to identify beta-blockers. Time of dose, route of administration, specimen tested and therapeutic concentration of the drug were found to be factors in the ability of the laboratory to identify beta-blockers in postmortem specimens. (Published by Oxford University Press 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.)
Databáze:	MEDLINE
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