Age-dependent association of thyroid function with brain morphology and microstructural organization: evidence from brain imaging.

Autor: Chaker L; Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Cremers LGM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Korevaar TIM; Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., de Groot M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, the Netherlands., Dehghan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Niessen WJ; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, the Netherlands; Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands., Peeters RP; Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address: r.peeters@erasmusmc.nl., Vernooij MW; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2018 Jan; Vol. 61, pp. 44-51. Date of Electronic Publication: 2017 Sep 22.
DOI: 10.1016/j.neurobiolaging.2017.09.014
Abstrakt: Thyroid hormone (TH) is crucial during neurodevelopment, but high levels of TH have been linked to neurodegenerative disorders. No data on the association of thyroid function with brain imaging in the general population are available. We therefore investigated the association of thyroid-stimulating hormone and free thyroxine (FT4) with magnetic resonance imaging (MRI)-derived total intracranial volume, brain tissue volumes, and diffusion tensor imaging measures of white matter microstructure in 4683 dementia- and stroke-free participants (mean age 60.2, range 45.6-89.9 years). Higher FT4 levels were associated with larger total intracranial volumes (β = 6.73 mL, 95% confidence interval = 2.94-9.80). Higher FT4 levels were also associated with larger total brain and white matter volumes in younger individuals, but with smaller total brain and white matter volume in older individuals (p-interaction 0.02). There was a similar interaction by age for the association of FT4 with mean diffusivity on diffusion tensor imaging (p-interaction 0.026). These results are in line with differential effects of TH during neurodevelopmental and neurodegenerative processes and can improve the understanding of the role of thyroid function in neurodegenerative disorders.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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