Tonic inhibition of brown adipose tissue sympathetic nerve activity via muscarinic acetylcholine receptors in the rostral raphe pallidus.
Autor: | Conceição EPS; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, 97239, USA., Madden CJ; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, 97239, USA., Morrison SF; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, 97239, USA. |
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Jazyk: | angličtina |
Zdroj: | The Journal of physiology [J Physiol] 2017 Dec 15; Vol. 595 (24), pp. 7495-7508. Date of Electronic Publication: 2017 Nov 21. |
DOI: | 10.1113/JP275299 |
Abstrakt: | Key Points: A tonically active, muscarinic cholinergic inhibition of rostral raphe pallidus (rRPa) neurons influences thermogenesis of brown adipose tissue (BAT) independent of ambient temperature conditions. The tonically active cholinergic input to rRPa originates caudal to the hypothalamus. Muscarinic acetylcholine receptor (mAChR) activation in rRPa contributes to the inhibition of BAT sympathetic nerve activity (SNA) evoked by activation of neurons in the rostral ventrolateral medulla (RVLM). The RVLM is not the sole source of the muscarinic cholinergic input to rRPa. Activation of GABA receptors in rRPa does not mediate the cholinergic inhibition of BAT SNA. Abstract: We sought to determine if body temperature and energy expenditure are influenced by a cholinergic input to neurons in the rostral raphe pallidus (rRPa), the site of sympathetic premotor neurons controlling thermogenesis of brown adipose tissue (BAT). Nanoinjections of the muscarinic acetylcholine receptor (mAChR) agonist, oxotremorine, or the cholinesterase inhibitor, neostigmine (NEOS), in the rRPa of anaesthetized rats decreased cold-evoked BAT sympathetic nerve activity (SNA, nadirs: -72 and -95%), BAT temperature (Tbat, -0.5 and -0.6°C), expired CO (© 2017 The Authors. The Journal of Physiology © 2017 The Physiological Society.) |
Databáze: | MEDLINE |
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