Ocular Toxoplasmosis in Tropical Areas: Analysis and Outcome of 190 Patients from a Multicenter Collaborative Study.

Autor: Huang PK; a National Healthcare Group Eye Institute , Tan Tock Seng Hospital , Singapore , Singapore., Jianping C; a National Healthcare Group Eye Institute , Tan Tock Seng Hospital , Singapore , Singapore., Vasconcelos-Santos DV; b Department of Ophthalmology , Faculdade de Medicina and Hospital São Geraldo/Hospital das Clínicas da Universidade Federal de Minas Gerais , Belo Horizonte , Brazil., Arruda JSD; b Department of Ophthalmology , Faculdade de Medicina and Hospital São Geraldo/Hospital das Clínicas da Universidade Federal de Minas Gerais , Belo Horizonte , Brazil., Dutta Majumder P; c Medical Research Foundation , Sankara Netralaya , Chennai , Tamil Nadu , India., Anthony E; c Medical Research Foundation , Sankara Netralaya , Chennai , Tamil Nadu , India., Ganesh SK; c Medical Research Foundation , Sankara Netralaya , Chennai , Tamil Nadu , India., Biswas J; c Medical Research Foundation , Sankara Netralaya , Chennai , Tamil Nadu , India., Ling HS; a National Healthcare Group Eye Institute , Tan Tock Seng Hospital , Singapore , Singapore., Teoh SC; d Eagle Eye Centre , Mt Alvernia Hospital , Singapore , Singapore., Agrawal R; a National Healthcare Group Eye Institute , Tan Tock Seng Hospital , Singapore , Singapore.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2018; Vol. 26 (8), pp. 1289-1296. Date of Electronic Publication: 2017 Oct 11.
DOI: 10.1080/09273948.2017.1367407
Abstrakt: Purpose: To describe clinical findings and outcomes for ocular toxoplasmosis in an international multicenter collaborative study.
Methods: Retrospective analysis of 190 patients diagnosed with ocular toxoplasmosis from three study sites (Brazil, India, and Singapore).
Results: There were 93 (48.9%) females with a mean age of 32.8 years. The most common symptoms were isolated blurring of vision (36.8%), followed by blurring of vision with floaters (21.1%). Treatment regimens varied largely from monotherapy to multiple combination therapies. Final visual acuity of ≥20/40 was achieved in 106 (74.2%) patients. In a median follow-up period of 31 weeks (range 12-749 weeks), 83/190 (43.7%) patients suffered a relapse.
Conclusions: There appears to be geographical variation in the presentation of ocular toxoplasmosis. Compared to previous studies, we did not observe the '"dual peak" phenomenon of chronic and active disease based on age at presentation, and there was less bilateral and macular involvement (but more peripheral involvement).
Databáze: MEDLINE
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