| Autor: |
Linthicum DS; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston 77225., Bolger MB, Kussie PH, Albright GM, Linton TA, Combs S, Marchetti D |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical chemistry [Clin Chem] 1988 Sep; Vol. 34 (9), pp. 1676-80. |
| Abstrakt: |
Antibodies to small bioactive ligands and peptides may mimic the binding characteristics of the natural receptor; in turn, the anti-idiotypic antibodies generated against the binding sites of such anti-ligand antibodies may mimic some aspects of small bioactive ligands and peptides. Among the several levels of investigation of such antibody-receptor networks are (a) the quantitative structure-activity relationships of ligand binding to antibody as compared with natural receptor; (b) the molecular modeling of antibody-receptor binding sites and the genomic basis for such structures; and (c) the characteristics of the molecular mimicry exhibited by "mimetopes" on anti-idiotypic antibodies. To illustrate the analysis encountered at each of these levels, we discuss here antibody and anti-idiotypic systems that are directed to small neuroactive ligands and their receptors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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