The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression.

Autor:	Silva MJD; Sao Paulo State University, UNESP, Campus Litoral Paulista, Sao Vicente, SP, Brazil., Vilegas W; Sao Paulo State University, UNESP, Campus Litoral Paulista, Sao Vicente, SP, Brazil., da Silva MA; Department of Food and Drug, Federal University of Alfenas, UNIFAL, Alfenas, MG, Brazil., Paiotti APR; Department of Pathology., Pastrelo MM; Department of Pathology., Ruiz PLM; Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil., de Moura CFG; Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil., Oshima CTF; Department of Pathology., Ribeiro DA; Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Drug research [Drug Res (Stuttg)] 2018 Apr; Vol. 68 (4), pp. 196-204. Date of Electronic Publication: 2017 Oct 09.
DOI:	10.1055/s-0043-119750
Abstrakt:	The aim of this study was to evaluate the preventive and/or protective action of Mimosa caesalpiniifolia (M. caesalpiniifolia) following experimental colitis in rats. The rats were randomized into ten groups (n=10 per group), as follows: G1 - Sham group:; G2 - TNBS group; G3, G4 -colitis and treated with hydroalcoholic extract of M. caesalpiniifolia 250 mg/kg/day after and before/after inducing colitis, respectively; G5, G6 - colitis and treated with hydroalcoholic extract of M. caesalpiniifolia at 125 mg/kg/day after and before/after inducing colitis respectively; G7,G8 - colitis and treated with ethylacetate fraction of M. caesalpiniifolia at 50 mg/kg/day after and before/after inducing colitis, respectively; G9,G10 - colitis and treated with ethylacetate fraction of M. caesalpiniifolia at 50 mg/kg/day after and before/after inducing colitis, respectively. Rats treated with hydroalcoholic extract of M. caesalpiniifolia for both doses showed lower tissue damage in the distal colon. Ethylacetate fraction was effective at the highest dose only when administrated after inducing colitis. A downregulation of COX-2 was detected to rats suffering colitis and treated with M. caesalpiniifolia at high dose. On the other hand, TNF-alpha immunoexpression decreased in groups treated with M. caesalpiniifolia at low dose after inducing colitis. In summary, our results suggest that M. caesalpiniifolia attenuated the lesions of the colon, reduced inflammation, and modulates the expression of COX-2 and TNF-α during chronic colitis induced by TNBS when using for therapeutic purposes on a dose-dependent manner. Competing Interests: None declared. (© Georg Thieme Verlag KG Stuttgart · New York.)
Databáze:	MEDLINE
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