Collagenolytic Enzymes and their Applications in Biomedicine.

Autor:	Shekhter AB; Sechenov First Moscow State Medical University, Institute for Regenerative Medicine, Trubetskaya Str. 8, Moscow, 119991, Russian Federation., Balakireva AV; Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Trubetskaya Str. 8, Moscow, 119991, Russian Federation., Kuznetsova NV; Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Trubetskaya Str. 8, Moscow, 119991, Russian Federation., Vukolova MN; Sechenov First Moscow State Medical University, Department of Pathophysiology, Trubetskaya Str. 8, Moscow, 119991, Russian Federation., Litvitsky PF; Sechenov First Moscow State Medical University, Department of Pathophysiology, Trubetskaya Str. 8, Moscow, 119991, Russian Federation., Zamyatnin AA Jr; Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Trubetskaya Str. 8, Moscow, 119991, Russian Federation.; Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow, 119992, Russian Federation.
Jazyk:	angličtina
Zdroj:	Current medicinal chemistry [Curr Med Chem] 2019; Vol. 26 (3), pp. 487-505.
DOI:	10.2174/0929867324666171006124236
Abstrakt:	Nowadays, enzymatic therapy is a very promising line of treatment for many different diseases. There is a group of disorders and conditions, caused by fibrotic and scar processes and associated with the excessive accumulation of collagen that needs to be catabolized to normalize the connective tissue content. The human body normally synthesizes special extracellular enzymes, matrix metalloproteases (MMPs) by itself. These enzymes can cleave components of extracellular matrix (ECM) and different types of collagen and thus maintain the balance of the connective tissue components. MMPs are multifunctional enzymes and are involved in a variety of organism processes. However, under pathological conditions, the function of MMPs is not sufficient, and these enzymes fail to deal with disease. Thus, medical intervention is required. Enzymatic therapy is a very effective way of treating such collagen-associated conditions. It involves the application of exogenous collagenolytic enzymes that catabolize excessive collagen at the affected site and lead to the successful elimination of disease. Such collagenolytic enzymes are synthesized by many organisms: bacteria, animals (especially marine organisms), plants and fungi. The most studied and commercially available are collagenases from Clostridium histolyticum and from the pancreas of the crab Paralithodes camtschatica, due to their ability to effectively hydrolyse human collagen without affecting other tissues, and their wide pH ranges of collagenolytic activity. In the present review, we summarize not only the data concerning existing collagenase-based medications and their applications in different collagen-related diseases and conditions, but we also propose collagenases from different sources for their potential application in enzymatic therapy. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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