Achieving High 1 H Nuclear Hyperpolarization Levels with Long Lifetimes in a Range of Tuberculosis Drug Scaffolds.
| Autor: | Norcott P; Centre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of York, York, YO10 5NY, UK., Rayner PJ; Centre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of York, York, YO10 5NY, UK., Green GGR; Centre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of York, York, YO10 5NY, UK., Duckett SB; Centre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of York, York, YO10 5NY, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 Dec 01; Vol. 23 (67), pp. 16990-16997. Date of Electronic Publication: 2017 Nov 14. |
| DOI: | 10.1002/chem.201703278 |
| Abstrakt: | Despite the successful use of isoniazid, rifampicin, pyrazinamide and ethambutol in the treatment of tuberculosis (TB), it is a disease of growing global concern. We illustrate here a series of methods that will dramatically improve the magnetic resonance imaging (MRI) detectability of nineteen TB-relevant agents. We note that the future probing of their uptake and distribution in vivo would be expected to significantly enhance their efficacy in disease treatment. This improvement in detectability is achieved by use of the parahydrogen based SABRE protocol in conjunction with the 2 H-labelling of key sites within their molecular structures and the 2 H-labelling of the magnetization transfer catalyst. The T (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.) |
| Databáze: | MEDLINE |
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