Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes.

Autor: Bhatt AA; Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India., Choudhari PK; Department of Dietetics and Nutrition, Chellaram Diabetes Institute, Pune, Maharashtra, India., Mahajan RR; Department of Dietetics and Nutrition, Chellaram Diabetes Institute, Pune, Maharashtra, India., Sayyad MG; Department of Biostatistics, Chellaram Diabetes Institute, Pune, Maharashtra, India., Pratyush DD; Department of Research, Chellaram Diabetes Institute, Pune, Maharashtra, India., Hasan I; Department of Pathology, Chellaram Diabetes Institute, Pune, Maharashtra, India., Javherani RS; Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India., Bothale MM; Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India., Purandare VB; Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India., Unnikrishnan AG; Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India.
Jazyk: angličtina
Zdroj: Indian journal of endocrinology and metabolism [Indian J Endocrinol Metab] 2017 Sep-Oct; Vol. 21 (5), pp. 776-780.
DOI: 10.4103/ijem.IJEM_206_17
Abstrakt: Introduction: Type 2 diabetes mellitus (T2DM) is considered to be an inevitably progressive disease. Complex therapies add to the financial and psychological burden. Very low-calorie diets (LCDs) are emerging as an option in the management of type 2 diabetes.
Methods: We performed a clinical audit of patients with T2DM who received 12 weeks of LCD.
Results: This case series documents that 6 out of 12 participants (median baseline HbA1c 9%) achieved HbA1c level in nondiabetes range with LCD despite stopping all antidiabetes medications. There was an improvement in serum triglycerides, HDL cholesterol, total cholesterol, C-Reactive protein, urine microalbumin, liver transaminases, liver fat and the indices of insulin resistance, beta cell secretory capacity, and insulin sensitivity.
Conclusion: If long-term follow-up proves sustained benefits, such dietary restriction may be an alternative to more drastic options for reversal of type 2 diabetes. This may also help in changing the treatment perspective of a newly detected T2DM from an incurable and inevitably progressive disease to a potentially reversible disease.
Competing Interests: There are no conflicts of interest.
Databáze: MEDLINE
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