Plasma N-terminal pro-brain natriuretic peptide concentrations before and after pericardiocentesis in dogs with cardiac tamponade secondary to spontaneous pericardial effusion.

Autor: Baumwart RD; Department of Veterinary Clinical Sciences, Oklahoma State University, 2065 W. Farm Rd., Stillwater, OK 74078, United States. Electronic address: ryan.baumwart@okstate.edu., Hanzlicek AS; Department of Veterinary Clinical Sciences, Oklahoma State University, 2065 W. Farm Rd., Stillwater, OK 74078, United States., Lyon SD; Department of Veterinary Clinical Sciences, Oklahoma State University, 2065 W. Farm Rd., Stillwater, OK 74078, United States., Lee PM; Department of Veterinary Clinical Sciences, Washington State University, PO Box 647060, Pullman, WA 99164-7060, United States.
Jazyk: angličtina
Zdroj: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology [J Vet Cardiol] 2017 Oct; Vol. 19 (5), pp. 416-420. Date of Electronic Publication: 2017 Oct 04.
DOI: 10.1016/j.jvc.2017.08.007
Abstrakt: Objective: To determine if concentrations of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) are increased in dogs with cardiac tamponade and if there is a significant increase in plasma NT-proBNP after pericardiocentesis.
Animals: Ten client-owned dogs with spontaneous cardiac tamponade.
Methods: Prospective clinical study. Cardiac tamponade was suspected from physical examination and confirmed with echocardiography. Blood was collected and plasma NT-proBNP concentrations were measured before and 30-60 min following pericardiocentesis and resolution of cardiac tamponade. Within-subject changes in plasma NT-proBNP were compared by the Wilcoxon signed-rank test.
Results: The plasma NT-proBNP concentrations measured within the reference interval in seven of 10 dogs before pericardiocentesis and in six of 10 dogs following pericardiocentesis. Following pericardiocentesis, there was a statistically significant increase in median NT-proBNP concentration (733 pmol/L, range 250-3,297) compared with the values measured before (643 pmol/L, range 250-3,210, P = 0.004). The NT-proBNP concentration increased in 90% of the dogs following pericardiocentesis.
Conclusions: An upper reference limit of 900 pmol/L for plasma NT-proBNP is insensitive for the diagnosis of pericardial effusion and cardiac tamponade in dogs. Plasma NT-proBNP concentration commonly increases following pericardiocentesis, perhaps related to improved ventricular filling and stretch.
(Published by Elsevier B.V.)
Databáze: MEDLINE
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