Gender differences in the prevalence of congenital heart disease in Down's syndrome: a brief meta-analysis.
| Autor: | Diogenes TCP; Círculo do Coração de Pernambuco, Recife, Pernambuco, Brazil.; Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil., Mourato FA; Círculo do Coração de Pernambuco, Recife, Pernambuco, Brazil. felipe.a.mourato@gmail.com.; Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil. felipe.a.mourato@gmail.com.; Unidade de Cardiologia Materno e Fetal (UCMF), Av. Governador Agamenon Magalhães, 4760, Paissandu, PE, CEP 52010-902, Brazil. felipe.a.mourato@gmail.com., de Lima Filho JL; Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil., Mattos SDS; Círculo do Coração de Pernambuco, Recife, Pernambuco, Brazil.; Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | BMC medical genetics [BMC Med Genet] 2017 Oct 06; Vol. 18 (1), pp. 111. Date of Electronic Publication: 2017 Oct 06. |
| DOI: | 10.1186/s12881-017-0475-7 |
| Abstrakt: | Background: Down's syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40-60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them. Methods: We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included. Results: Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD. Conclusion: CHD, particularly AVSD, are more common in the female gender of Down's syndrome patients. |
| Databáze: | MEDLINE |
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