The Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre randomised controlled trial: baseline patient characteristics.

Autor:	Konstantakopoulou E; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Institute of Ophthalmology, University College London, London, UK., Gazzard G; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Institute of Ophthalmology, University College London, London, UK., Vickerstaff V; Marie Curie Palliative Care Research Department, UCL Division of Psychiatry, University College London, London, UK.; The Research Department of Primary Care and Population Health, University College London, London, UK., Jiang Y; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Institute of Ophthalmology, University College London, London, UK., Nathwani N; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK., Hunter R; Priment Clinical Trials Unit, University College London, Royal Free Medical School, London, UK., Ambler G; Department of Statistical Science, University College London, London, UK., Bunce C; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.; Department of Primary Care and Public Health, Kings College London, London, UK.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2018 May; Vol. 102 (5), pp. 599-603. Date of Electronic Publication: 2017 Oct 05.
DOI:	10.1136/bjophthalmol-2017-310870
Abstrakt:	Purpose: The laser in glaucoma and ocular hypertension (LiGHT) trial aims to establish whether initial treatment with selective laser trabeculoplasty (SLT) is superior to initial treatment with topical medication for primary open angle glaucoma (POAG) or ocular hypertension (OHT). Design: LiGHT is a prospective unmasked, multicentre, pragmatic, randomised controlled trial (RCT). Participants: 718 previously untreated patients with POAG or OHT were recruited at 6 UK centres between 2012 and 2014. Methods: Patients were randomised to initial SLT followed by medical therapy or medical therapy without laser. Participants will be monitored for 3 years, according to routine clinical practice. The primary outcome is EQ-5D-5L. Secondary outcomes are treatment pathway cost and cost-effectiveness, Glaucoma Utility Index (GUI), Glaucoma Symptom Scale, Glaucoma Quality of Life (GQL), pathway effectiveness, visual function, safety and concordance. Results: A total of 555 patients had POAG and 163 OHT; 518 patients had both eyes eligible. The mean age for patients with POAG was 64 years and for OHT 58 years. 70% of all participants were white. Median IOP for OHT eyes was 26 mm Hg and 23 mm Hg for POAG eyes. Median baseline visual field mean deviation was -0.81 dB for OHT eyes and -2.82 dB for POAG eyes. There was no difference between patients with POAG and patients with OHT on the EQ-5D-5DL; the difference between OHT and POAG on the GUI was -0.02 and 1.23 on the GQL. Conclusions: The LiGHT trial is the first RCT to compare the two treatment options in a real-world setting. The baseline characteristics of the LiGHT cohort compare well with other landmark glaucoma studies. Trial Registration Number: ISRCTN32038223, Pre-results. Competing Interests: Competing interests: GG, RH, GA and CB have received a grant from the NIHR for the submitted work. GG has received a research grant from Lumenis prior to the submitted work. (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
Databáze:	MEDLINE
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