Potential Biomarkers with Plasma Cortisol, Brain-derived Neurotrophic Factor and Nitrites in Patients with Acute Ischemic Stroke.

Autor:	Casas S; Servicio de Neurología, Hospital Militar Central-H Grl 601- ¨Cir My Dr. Cosme Argerich¨-, Buenos Aires, Argentina., Perez AF; Servicio de Neurología, Hospital Militar Central-H Grl 601- ¨Cir My Dr. Cosme Argerich¨-, Buenos Aires, Argentina., Mattiazzi M; Servicio de Neurología, Hospital Militar Central-H Grl 601- ¨Cir My Dr. Cosme Argerich¨-, Buenos Aires, Argentina., Lopez J; Servicio de Neurología, Hospital Militar Central-H Grl 601- ¨Cir My Dr. Cosme Argerich¨-, Buenos Aires, Argentina., Folgueira A; Servicio de Neurología, Hospital Militar Central-H Grl 601- ¨Cir My Dr. Cosme Argerich¨-, Buenos Aires, Argentina., Gargiulo-Monachelli GM; Laboratorio de Bioquimica Neuroendocrina, Instituto de Biología y Medicina Experimental (IBYME)-CONICET, Buenos Aires, Argentina., Gonzalez Deniselle MC; Laboratorio de Bioquimica Neuroendocrina, Instituto de Biología y Medicina Experimental (IBYME)-CONICET, Buenos Aires, Argentina., De Nicola AF; Laboratorio de Bioquimica Neuroendocrina, Instituto de Biología y Medicina Experimental (IBYME)-CONICET, Buenos Aires, Argentina.
Jazyk:	angličtina
Zdroj:	Current neurovascular research [Curr Neurovasc Res] 2017; Vol. 14 (4), pp. 338-346.
DOI:	10.2174/1567202614666171005122925
Abstrakt:	Background: Acute Ischemic Stroke (AIS) represents an economic challenge for health systems all over the globe. Changes of neuroactive steroids have been found in different neurological diseases. We have previously demonstrated that old patients with AIS show changes of plasma cortisol and estradiol concentrations, in that increased steroid levels are associated with a deterioration of neurological status and a worse cognitive decline. Objective: The present study assessed in patients with AIS if changes of behavior, Brain-Derived Neurotrophic Factor (BDNF) and Nitrites (NO-2) bear a relationship with the degree of hypercortisolism. Methods: We recruited patients hospitalized within the first 24 hours of AIS. Subjects were divided into two groups, each one composed of 40 control subjects and 40 AIS patients, including men and women. The neurological condition was assessed using the National Institute of Health Stroke Scale (NIHSS) and the cognitive status with the Montreal Cognitive Assessment (MoCA). The emotional status was evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS), whereas the Modified Rankin Scale (MRS) was used to determine the functional condition. BDNF and NO-2 plasma levels were measured by ELISA and the Griess reaction method, respectively. Results: We found that in AIS patients, increased plasma cortisol was negatively correlated with plasma BDNF and NO-2 levels, neurological condition, cognition, functional responses and emotional status, suggesting a relationship between the declines of clinical, behavioral and blood parameters with stress-induced cortisol elevation. Conclusion: Nitrites and BDNF may represent potential biomarkers for cortisol negative effects on the area of cerebral ischemia and penumbra, potentiating ischemic cell damage. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
Databáze:	MEDLINE
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