[Association of transcobalamine II gene polymorphisms and serum homocysteine, vitamin B 12 and folate levels with ulcerative colitis among Chinese patients].
Autor: | Zheng S; Department of Gastroenterology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. wzjiangyi@yeah.net., Wu H, Ye F, Xia X, Xia S, Lin X, Wu X, Jiang L, Ding R, Jiang Y |
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Jazyk: | čínština |
Zdroj: | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2017 Oct 10; Vol. 34 (5), pp. 731-736. |
DOI: | 10.3760/cma.j.issn.1003-9406.2017.05.025 |
Abstrakt: | Objective: To assess the association of transcobalamine II (TCN2) gene polymorphisms and serum levels of homocysteine (Hcy), vitamin B Methods: For 397 UC patients and 574 controls, two single nucleotide polymorphisms of the TCN2 gene (rs1801198, rs9606756) were tested with an improved multiple ligase detection reaction method. Serum Hcy, vitamin B Results: The allelic and genotypic frequencies of rs1801198 and rs9606756 did not differ significantly between the two groups (all P> 0.05). Compared with those of the control group, the frequencies of G allele and CG+GG genotype of rs1801198 were greater in patients with moderate and severe UC (both P< 0.05). The same conclusion may also be drawn for the G allele and AG genotype of rs9606756 (both P< 0.05). Compared with the controls, average Hcy level was enhanced in UC patients (P< 0.01), whereas average vitamin B Conclusion: TCN2 (rs1801198, rs9606756) variations, as well as serum levels of Hcy, vitamin B |
Databáze: | MEDLINE |
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