Assessment of the antioxidant, thrombolytic, analgesic, anti-inflammatory, antidepressant and anxiolytic activities of leaf extracts and fractions of Tetracera sarmentosa (L.) Vahl.

Autor:	Uddin MMN; Department of Pharmacy, Faculty of Biological Science, University of Chittagong, Chittagong 4331, Bangladesh., Kabir MSH; Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh., Hasan M; Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh., Al Mahmud Z; Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh., Alam Bhuiya NMM; Department of Pharmacy, Faculty of Biological Science, University of Chittagong, Chittagong 4331, Bangladesh., Ahmed F; Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh., Hasan MR; Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh., Hosen MT; Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh., Alam MS; Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh.
Jazyk:	angličtina
Zdroj:	Journal of basic and clinical physiology and pharmacology [J Basic Clin Physiol Pharmacol] 2018 Jan 26; Vol. 29 (1), pp. 81-93.
DOI:	10.1515/jbcpp-2016-0173
Abstrakt:	Background: The plant under investigation (Tetracera sarmentosa) is a dicotyledonous flowering plant and belongs to the family Dilleniaceae. The goal of our investigation was to determine whether the leaf extracts of this plant held any significant medicinal properties. Methods: Leaves of T. sarmentosa were extracted with pure ethanol (EETS) and methanol (METS), and then methanol extract fractioned with n-hexane (NHFMETS) and chloroform (CHFMETS). The extracts and fractions were tested for antioxidant activity, which was measured by using qualitative and quantitative procedures. Thrombolytic activity was evaluated by the clot lysis test. Analgesic activity was evaluated employing the acidic acid-induced writhing test, the formalin-induced paw licking test and tail immersion on Swiss albino mice. The anti-inflammatory activity test was studied using the paw edema test. Forced swimming, tail suspension, elevated plus maze and hole board model tests were used to evaluate neuropharmacological activity. Results: All the extracts and fractions possessed antioxidant effects. All the extracts, fractions and streptokinase exhibited significant (p<0.0001) clot lysis. The extracts and fractions produced significant analgesic effects as evaluated by the acetic acid writhing test, the formalin-induced paw licking test and the tail immersion method. Similarly, carrageenan-induced inflammation was significantly antagonized by the treatments. The extracts and fractions also significantly showed neuropharmacological (antidepressant and anxiolytic) effects. Conclusions: The overall results suggested that this plant deserves further investigation to isolate the active compounds which are responsible for these activities and to establish the mechanism of action.
Databáze:	MEDLINE
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