| Autor: |
Peak CW; Biomedical Engineering and ‡Material Science and Engineering, Dwight Look College of Engineering, and §Center for Remote Health Technologies and Systems, Texas A&M University , College Station, Texas 77843, United States., Stein J; Biomedical Engineering and ‡Material Science and Engineering, Dwight Look College of Engineering, and §Center for Remote Health Technologies and Systems, Texas A&M University , College Station, Texas 77843, United States., Gold KA; Biomedical Engineering and ‡Material Science and Engineering, Dwight Look College of Engineering, and §Center for Remote Health Technologies and Systems, Texas A&M University , College Station, Texas 77843, United States., Gaharwar AK; Biomedical Engineering and ‡Material Science and Engineering, Dwight Look College of Engineering, and §Center for Remote Health Technologies and Systems, Texas A&M University , College Station, Texas 77843, United States. |
| Abstrakt: |
Nanoengineered hydrogels offer the potential to design shear-thinning bioinks for three-dimensional (3D) bioprinting. Here, we have synthesized colloidal bioinks composed of disk-shaped two-dimensional (2D) nanosilicates (Laponite) and poly(ethylene glycol) (PEG). The addition of Laponite reinforces the PEG network and increases viscosity, storage modulus, and network stability. PEG-Laponite hydrogels display shear-thinning and self-recovery characteristics due to rapid internal phase rearrangement. As a result, a range of complex patterns can be printed using PEG-Laponite bioinks. The 3D bioprinted structure has similar mechanical properties compared to the as-casted structure. In addition, encapsulated cells within the PEG-Laponite bioink show high viability after bioprinting. Overall, this study introduces a new class of PEG-Laponite colloidal inks for bioprinting and cell delivery. |
