[The effect of intracerebral transplantation of mesenchymal stem cells on orientation and exploratory behavior of aged animals].

Autor:	Sokolova IB; I. P. Pavlov Institute of Physiology, RAS, St. Petersburg, 199034, Russian Federation; sib@kolt.infran.ru., Fedotova OR; Research Institute of Experimental Medicine, RAMS, St. Petersburg, 197376, Russian Federation., Gilerovich EG; Research Institute of Experimental Medicine, RAMS, St. Petersburg, 197376, Russian Federation., Sergeev IV; I. P. Pavlov Institute of Physiology, RAS, St. Petersburg, 199034, Russian Federation; sib@kolt.infran.ru., Anisimov SV; V. A. Almazov Federal Center for Heart, Blood and Endocrinology, St. Petersburg, 197341, Russian Federation., Puzanov MV; V. A. Almazov Federal Center for Heart, Blood and Endocrinology, St. Petersburg, 197341, Russian Federation., Dvoretsky DP; I. P. Pavlov Institute of Physiology, RAS, St. Petersburg, 199034, Russian Federation; sib@kolt.infran.ru.
Jazyk:	ruština
Zdroj:	Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2013; Vol. 26 (2), pp. 236-241.
Abstrakt:	Male Wistar-Kyoto rats (12 and 22-24 months old) were intracerebrally transplantated with syngeneic mesenchymal stem cells (MSC). Three weeks or one year later, orientation and exploratory behavior of the same animals (not 2 years old) was assessed using an «open field» test. Older rats (22-24 months old) were inhibited in the basic behavioral acts in comparison to younger animals (2-3 months old). Transplantation of MSC did not cause improvement of an orientation and exploratory behavior of aged rats. Morphological and immunohistochemical analysis suggests intracerebral MSC transplantation led to the injury of the cortex of the ipsilateral hemisphere.
Databáze:	MEDLINE
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