Influence of Apolipoprotein E on the Lipid Profile and Postprandial Triglyceride Levels in Brazilian Postmenopausal Women With Artery Disease.

Autor: Tácito LHB; Endocrinology Division, Internal Medicine Department, State Medical School of São José Rio Preto (FAMERP), São José do Rio Preto, Brazil., Yamada LN; Molecular Biology and Biochemistry Department, State Medical School of São José Rio Preto (FAMERP), São José do Rio Preto, Brazil., de Souza Pinhel MA; Molecular Biology and Biochemistry Department, State Medical School of São José Rio Preto (FAMERP), São José do Rio Preto, Brazil., Yugar-Toledo JC; Internal Medicine Department, State Medical School of São José Rio Preto (FAMERP), São José do Rio Preto, Brazil., Souza DRS; Molecular Biology and Biochemistry Department, State Medical School of São José Rio Preto (FAMERP), São José do Rio Preto, Brazil.
Jazyk: angličtina
Zdroj: Clinical Medicine Insights. Cardiology [Clin Med Insights Cardiol] 2017 Sep 21; Vol. 11, pp. 1179546817731110. Date of Electronic Publication: 2017 Sep 21 (Print Publication: 2017).
DOI: 10.1177/1179546817731110
Abstrakt: This study confirms the association of risk factors for coronary artery disease (CAD) and the apoE polymorphisms, specifically related to the APOE*4 allele, with coronary disease in postmenopausal women. Significantly altered values of the lipid profile were found in patients when compared with controls, independent of the presence of the APOE*4 allele. However, the controls showed higher high-density lipoprotein cholesterol (HDL-C) levels and reduced triglyceride (TG) levels, differing significantly from patients. In this case, the study of subgroups, considering the APOE*3/3 and APOE*3/4 genotypes, suggests that the APOE*4 allele is not implicated in the variations of the lipid profile of patients and determined an increase in the production levels of HDL-C and a reduction in TG highly benefiting the control group compared with APOE*3/3 genotype. The metabolic kinetics of TG, although with the same pattern between groups, and the presence of the APOE*4 allele are suggested to be associated with accelerated clearance compared with APOE*3 allele in non-CAD group.
Competing Interests: Declaration of Conflicting Interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
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