Long-term outcomes of patients with Streptococcus suis infection in Viet Nam: A case-control study.

Autor: Huong VTL; Wellcome Trust Major Overseas Programme - Oxford University Clinical Research Unit, 78 Giai Phong, Dong Da, Ha Noi, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3BD, UK. Electronic address: huongvtl@oucru.org., Long HB; Wellcome Trust Major Overseas Programme - Oxford University Clinical Research Unit, 78 Giai Phong, Dong Da, Ha Noi, Viet Nam., Kinh NV; National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da, Hanoi, Viet Nam., Ngan TTD; National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da, Hanoi, Viet Nam., Dung VTV; Wellcome Trust Major Overseas Programme - Oxford University Clinical Research Unit, 78 Giai Phong, Dong Da, Ha Noi, Viet Nam., Nadjm B; Wellcome Trust Major Overseas Programme - Oxford University Clinical Research Unit, 78 Giai Phong, Dong Da, Ha Noi, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3BD, UK., van Doorn HR; Wellcome Trust Major Overseas Programme - Oxford University Clinical Research Unit, 78 Giai Phong, Dong Da, Ha Noi, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3BD, UK., Hoa NT; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3BD, UK; Wellcome Trust Major Overseas Programme - Oxford University Clinical Research Unit, 764 Vo Van Kiet, Ho Chi Minh, Viet Nam; Department of Biology and Biotechnology, University of Science -National University, Ho Chi Minh, Viet Nam., Horby P; Wellcome Trust Major Overseas Programme - Oxford University Clinical Research Unit, 78 Giai Phong, Dong Da, Ha Noi, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3BD, UK., Wertheim HFL; Wellcome Trust Major Overseas Programme - Oxford University Clinical Research Unit, 78 Giai Phong, Dong Da, Ha Noi, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3BD, UK; Radboud UMC, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Jazyk: angličtina
Zdroj: The Journal of infection [J Infect] 2018 Feb; Vol. 76 (2), pp. 159-167. Date of Electronic Publication: 2017 Sep 29.
DOI: 10.1016/j.jinf.2017.09.019
Abstrakt: Objectives: Streptococcus suis is a zoonotic cause of severe meningitis and sepsis in humans. We aimed to assess the long-term outcomes in patients who survived S. suis infection, in particular the progress and impact of vestibulocochlear sequelae.
Methods: This case-control study evaluated outcomes of S. suis infection at discharge and 3 and 9 months post-discharge for 47 prospectively enrolled cases and at 11-34 months for 31 retrospectively enrolled cases. Outcomes in patients were compared to 270 controls matched for age, sex and residency.
Results: The prevalence ratio (PR) of moderate-to-complete hearing loss was 5.0(95%CI 3.6-7.1) in cases at discharge, 3.7(2.5-5.4) at 3 months, 3.2(2.2-4.7) at 9 months, and 3.1(2.1-4.4) in retrospective cases compared to controls. Hearing improvement occurred mostly within the first 3 months with a change in hearing level of 11.1%(95%CI 7.0-15.1%) compared to discharge. The PR of vestibular dysfunction was 2.4(95%CI 1.7-3.3) at discharge, 2.2(1.4-3.1) at 3 months, 1.8(1.1-2.5) at 9 months, and 1.8(1.1-2.6) for retrospective cases compared to controls. Cases also indicated more problems with mobility, self-care and usual activities.
Conclusions: Both hearing and vestibular impairment were common and persist in cases. Appropriate patient management strategies are needed to reduce the incidence and impact of these sequelae.
(Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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