The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery against cestode infection of animals.

Autor: Arkhipov IA; All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin, Bolshaya Cheremushkinskaya street 28, 117218 Moscow, Russia., Sadov KM; Scientific Research Veterinary Station of the Russian Academy of Agricultural Sciences, Magnitogorskaya street 8, 446013 Samara, Russia., Limova YV; Scientific Research Veterinary Station of the Russian Academy of Agricultural Sciences, Magnitogorskaya street 8, 446013 Samara, Russia., Sadova AK; Scientific Research Veterinary Station of the Russian Academy of Agricultural Sciences, Magnitogorskaya street 8, 446013 Samara, Russia., Varlamova AI; All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin, Bolshaya Cheremushkinskaya street 28, 117218 Moscow, Russia. Electronic address: arsphoeb@mail.ru., Khalikov SS; A.N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Vavilova street 28, 119991 Moscow, Russia., Dushkin AV; Institute of Solid State Chemistry and Mechanochemistry of the Siberian Branch of the Russian Academy of Sciences, 630128, Novosibirsk, Kutateladze str., 18, Russia., Chistyachenko YS; Institute of Solid State Chemistry and Mechanochemistry of the Siberian Branch of the Russian Academy of Sciences, 630128, Novosibirsk, Kutateladze str., 18, Russia.
Jazyk: angličtina
Zdroj: Veterinary parasitology [Vet Parasitol] 2017 Nov 15; Vol. 246, pp. 25-29. Date of Electronic Publication: 2017 Sep 01.
DOI: 10.1016/j.vetpar.2017.08.019
Abstrakt: Niclosamide is an anthelmintic that is widely used to treat cestode infection of animals. The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery was studied in hymenolepiosis of mice and monieziosis of sheep. The efficacy of new substances of niclosamide with polyvinylpyrrolidone polymer in different ratios (1:10; 1:5; 1:2) was determined by the results of helminthological necropsy of the small intestine of sheep and mice. Pre-treatment eggs per gram (EPG) were not significantly different (P>0.1) among groups. The controlled test was used to evaluate the efficacy. A high efficacy (>95% efficacy) of the supramolecular complexes of niclosamide with PVP (SCoNwPVP) was shown in different ratios (1:10; 1:5 and 1:2) at a dose of 20mg/kg of body weight at oral administration against Hymenolepis nana in mice and Moniezia expansa in sheep. Whereas the basic drug - substance of niclosamide was effective at a dose of 100mg/kg of b/w. No adverse effects of the drugs on animal health were detected during the study.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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