High prevalence of Seoul hantavirus in a breeding colony of pet rats.

Autor:	McELHINNEY LM; Department of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK., Marston DA; Department of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK., Pounder KC; HPRU Emerging and Zoonotic Infections,Institute of Infection and Global Health,University of Liverpool,Liverpool,UK., Goharriz H; Department of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK., Wise EL; Department of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK., Verner-Carlsson J; Department of Medical Biochemistry and Microbiology and Department of Medical Sciences,Zoonosis Science Centre,Uppsala University,Uppsala,Sweden., Jennings D; Department of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK., Johnson N; Department of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK., Civello A; Department of Pathology,APHA,Weybridge,Surrey,UK., Nunez A; Department of Pathology,APHA,Weybridge,Surrey,UK., Brooks T; HPRU Emerging and Zoonotic Infections,Institute of Infection and Global Health,University of Liverpool,Liverpool,UK., Breed AC; Department of Epidemiological Sciences,APHA,Weybridge,Surrey,UK., Lawes J; Department of Epidemiological Sciences,APHA,Weybridge,Surrey,UK., Lundkvist Å; Department of Medical Biochemistry and Microbiology and Department of Medical Sciences,Zoonosis Science Centre,Uppsala University,Uppsala,Sweden., Featherstone CA; APHA,Thirsk Veterinary Investigation Centre,Thirsk,UK., Fooks AR; Department of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK.
Jazyk:	angličtina
Zdroj:	Epidemiology and infection [Epidemiol Infect] 2017 Nov; Vol. 145 (15), pp. 3115-3124. Date of Electronic Publication: 2017 Oct 02.
DOI:	10.1017/S0950268817001819
Abstrakt:	As part of further investigations into three linked haemorrhagic fever with renal syndrome (HFRS) cases in Wales and England, 21 rats from a breeding colony in Cherwell, and three rats from a household in Cheltenham were screened for hantavirus. Hantavirus RNA was detected in either the lungs and/or kidney of 17/21 (81%) of the Cherwell rats tested, higher than previously detected by blood testing alone (7/21, 33%), and in the kidneys of all three Cheltenham rats. The partial L gene sequences obtained from 10 of the Cherwell rats and the three Cheltenham rats were identical to each other and the previously reported UK Cherwell strain. Seoul hantavirus (SEOV) RNA was detected in the heart, kidney, lung, salivary gland and spleen (but not in the liver) of an individual rat from the Cherwell colony suspected of being the source of SEOV. Serum from 20/20 of the Cherwell rats and two associated HFRS cases had high levels of SEOV-specific antibodies (by virus neutralisation). The high prevalence of SEOV in both sites and the moderately severe disease in the pet rat owners suggest that SEOV in pet rats poses a greater public health risk than previously considered.
Databáze:	MEDLINE
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