| Autor: |
Ferreira AC; Laboratorio de Gastroenterologia e Hepatologia Tropical LIM/07, Instituto de Medicina Tropical da USP, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Enéas Carvalho de Aguiar, 500, Sao Paulo, SP, 05403-000, Brazil., Gomes-Gouvêa MS; Laboratorio de Gastroenterologia e Hepatologia Tropical LIM/07, Instituto de Medicina Tropical da USP, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Enéas Carvalho de Aguiar, 500, Sao Paulo, SP, 05403-000, Brazil. gomesmic@yahoo.com.br., Lisboa-Neto G; Laboratorio de Virologia LIM/52, Instituto de Medicina Tropical da USP, Departamento de Doenças Infecciosas e Parasitarias, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Mendes-Correa MCJ; Laboratorio de Virologia LIM/52, Instituto de Medicina Tropical da USP, Departamento de Doenças Infecciosas e Parasitarias, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Picone CM; Departamento de Doenças Infecciosas e Parasitarias, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Salles NA; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, Brazil., Mendrone-Junior A; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, Brazil., Carrilho FJ; Laboratorio de Gastroenterologia e Hepatologia Tropical LIM/07, Instituto de Medicina Tropical da USP, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Enéas Carvalho de Aguiar, 500, Sao Paulo, SP, 05403-000, Brazil., Pinho JRR; Laboratorio de Gastroenterologia e Hepatologia Tropical LIM/07, Instituto de Medicina Tropical da USP, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Enéas Carvalho de Aguiar, 500, Sao Paulo, SP, 05403-000, Brazil.; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil. |
| Abstrakt: |
In Brazil, the circulation of hepatitis E virus (HEV) has been demonstrated in distinct groups of individuals and some animals, but its prevalence among individuals with human immunodeficiency virus (HIV) infection is unknown. This study aimed to assess the frequency of serological and molecular HEV markers in individuals infected with HIV from São Paulo, Brazil. Serum and plasma samples of 354 HIV-infected patients collected between 2007 and 2013 were included. All samples were tested for anti-HEV IgG and IgM antibodies and HEV RNA. Anti-HEV IgG and IgM antibodies were detected in 10.7% (38/354) and 1.4% (5/354) of the samples, respectively. Both antibodies were detected simultaneously in only two samples. HEV RNA was not detected in any sample. There was no significant correlation of anti-HEV serological status (positivity to anti-HEV IgG and/or IgM) with sex, age, CD4 + T cell count, HIV viral load, antiretroviral therapy, liver enzyme levels, or coinfection with hepatitis B virus and/or hepatitis C virus. Our study provides serological evidence of past and recent HEV infections in HIV-infected patients from São Paulo, Brazil. However, the occurrence of ongoing HEV infection appears be a rare event in this population. |
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