Long-term therapy with intravenous zoledronate increases the number of nonattached osteoclasts.

Autor: Nagata MJH; University Estadual Paulista - UNESP, Dental School of Araçatuba, Department of Surgery and Integrated Clinic, Araçatuba, SP, Brazil. Electronic address: mjnagata@foa.unesp.br., Messora MR; University of São Paulo - USP, Ribeirão Preto School of Dentistry, Department of Oral and Maxillofacial Surgery and Traumatology and Periodontology, Ribeirão Preto, SP, Brazil., Antoniali C; University Estadual Paulista - UNESP, Dental School of Araçatuba, Department of Basic Sciences, Araçatuba, SP Brazil., Fucini SE; University Estadual Paulista - UNESP, Dental School of Araçatuba, Department of Surgery and Integrated Clinic, Araçatuba, SP, Brazil; Private Practice, NH, Hanover, USA., de Campos N; University Estadual Paulista - UNESP, Dental School of Araçatuba, Department of Surgery and Integrated Clinic, Araçatuba, SP, Brazil., Pola NM; Federal University of Pelotas - UFPel, Dental School of Pelotas, Department of Semiology and Clinic, Pelotas, RS, Brazil., Santinoni CS; University Do Oeste Paulista - UNOESTE, Dental School of Presidente Prudente, Division of Periodontics, Presidente Prudente, SP, Brazil., Furlaneto FAC; University of São Paulo - USP, Ribeirão Preto School of Dentistry, Department of Oral and Maxillofacial Surgery and Traumatology and Periodontology, Ribeirão Preto, SP, Brazil., Ervolino E; University Estadual Paulista - UNESP, Dental School of Araçatuba, Department of Basic Sciences, Araçatuba, SP Brazil.
Jazyk: angličtina
Zdroj: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery [J Craniomaxillofac Surg] 2017 Nov; Vol. 45 (11), pp. 1860-1867. Date of Electronic Publication: 2017 Aug 19.
DOI: 10.1016/j.jcms.2017.08.011
Abstrakt: The purpose of this study was to investigate the influence of long-term therapy with intravenous zoledronate (ZA) on the healing of extraction sockets in rats. Forty rats, divided into groups C (Control) and Z (Zoledronate), received intravenous injections of either saline solution or ZA for 24 weeks. Their right maxillary incisor was extracted. Euthanasia was performed at 7 or 28 days postoperative. Histomorphometric (Newly Formed Bone Area) and immunohistochemical (RANKL, OPG and TRAP) analyses were performed. Data were statistically analyzed (ANOVA, Tukey's test and Kruskal-Wallis, Dunn's Multiple Comparison test).Groups C and Z showed similar new bone area, RANKL and OPG immunolabeling. The number of TRAP-positive multinucleated cells was significantly higher in Group Z than in Group C at 28 days. A significantly higher proportion of nonattached osteoclasts were seen in Group Z than in Group C at both periods of analysis. Long-term therapy with intravenous ZA stimulated nonattached osteoclast formation in extraction sockets in rats, thus decreasing local bone resorption. However, it did not influence bone formation by osteoblasts.
(Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: