Undernutrition during pregnancy and lactation increases the number of fos-cells in the reward system in response to a 5-HT6 receptor agonist in male adolescent rats.

Autor: da Silva AAM; a Nursing College , Universidade de Pernambuco - Campus Petrolina - UPE , Recife , PE , Brazil., Oliveira MM; b Postgraduate Nutrition , Universidade Federal Pernambuco - UFPE , Recife , PE , Brazil., Cavalcante TCF; c Postgraduate Neuropsychiatry and Behavioral Sciences , Universidade Federal Pernambuco - UFPE , Recife , PE , Brazil., do Amaral Almeida LC; a Nursing College , Universidade de Pernambuco - Campus Petrolina - UPE , Recife , PE , Brazil., Cruz PLM; d Department of Nutrition , Universidade Federal de Pernambuco - UFPE , Recife , PE , Brazil., de Souza SL; a Nursing College , Universidade de Pernambuco - Campus Petrolina - UPE , Recife , PE , Brazil.; e Department of Anatomy , Universidade Federal de Pernambuco - UFPE , Recife , PE , Brazil.
Jazyk: angličtina
Zdroj: International journal of food sciences and nutrition [Int J Food Sci Nutr] 2018 Jun; Vol. 69 (4), pp. 488-493. Date of Electronic Publication: 2017 Sep 28.
DOI: 10.1080/09637486.2017.1382455
Abstrakt: Undernutrition promotes morphofunctional adaptations in neuroanatomical circuits, leading to behavioural changes. Adolescence is a period of vulnerability for these adaptations, such as the control of food intake and the serotonergic system. The serotonergic system is capable of promoting satiety. However, its role in hedonic control has not been fully elucidated. The involvement of the 5-HT6 receptor in motivational feeding behaviours was recently observed. Therefore, we aimed to evaluate the effect of a 5-HT6 receptor agonist on food intake and neuronal activation in areas of the reward system in adolescent rats subjected to perinatal protein undernutrition. Wistar rats were divided into two groups according to nutritional manipulation during gestation and lactation. It has been observed that undernourished animals present greater neuronal activation in response to the 5HT-6 receptor agonist in areas of the food reward system.
Databáze: MEDLINE
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