Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?

Autor: Cemil BC; Department of Dermatology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey., Yilmazer D; Department of Pathology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey., Atas H; Department of Dermatology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey., Cengiz FP; Department of Dermatovenereology, Bezmialem Vakif University, Istanbul, Turkey., Canpolat F; Department of Dermatology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey., Alper M; Department of Pathology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey., Gonul M; Department of Dermatology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Postepy dermatologii i alergologii [Postepy Dermatol Alergol] 2017 Aug; Vol. 34 (4), pp. 322-327. Date of Electronic Publication: 2017 Aug 01.
DOI: 10.5114/ada.2017.69311
Abstrakt: Introduction: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis.
Aim: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP.
Material and Methods: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group.
Results: The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls ( p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients.
Conclusions: Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.
Databáze: MEDLINE
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