Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.

Autor:	Sobrin L; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA., Chong YH; Duke-NUS Medical School, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Fan Q; Duke-NUS Medical School, National University of Singapore, Singapore., Gan A; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Stanwyck LK; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA., Kaidonis G; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Craig JE; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Kim J; Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX., Liao WL; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.; Center for Personalized Medicine, China Medical University Hospital, Taichung, Taiwan., Huang YC; School of Chinese Medicine, China Medical University, Taichung, Taiwan.; Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Hung YJ; Department of Internal Medicine, Tri-Service General Hospital, Taipei City, Taiwan., Guo X; Institute for Translational Genomics and Population Sciences, LA BioMed, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Hai Y; Institute for Translational Genomics and Population Sciences, LA BioMed, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Ipp E; Department of Medicine, LA BioMed, Harbor-UCLA Medical Center, Torrance, CA., Pollack S; Department of Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA., Hancock H; Department of Ophthalmology, The University of Mississippi Medical Center, Jackson, MS., Price A; Department of Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA., Penman A; Department of Medicine, The University of Mississippi Medical Center, Jackson, MS., Mitchell P; Centre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Liew G; Centre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Smith AV; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.; Icelandic Heart Association, Kópavogur, Iceland., Gudnason V; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.; Icelandic Heart Association, Kópavogur, Iceland., Tan G; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Klein BEK; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI., Kuo J; Institute for Translational Genomics and Population Sciences, LA BioMed, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.; Clinical and Medical Affairs, CardioDx, Inc., Redwood City, CA., Li X; Institute for Translational Genomics and Population Sciences, LA BioMed, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Christiansen MW; Cardiovascular Health Research Unit, Division of General Internal Medicine, University of Washington, Seattle, WA., Psaty BM; Cardiovascular Health Research Unit, Division of General Internal Medicine, University of Washington, Seattle, WA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA., Sandow K; Institute for Translational Genomics and Population Sciences, LA BioMed, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Jensen RA; Cardiovascular Health Research Unit, Division of General Internal Medicine, University of Washington, Seattle, WA., Klein R; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI., Cotch MF; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD., Wang JJ; Duke-NUS Medical School, National University of Singapore, Singapore.; Centre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Jia Y; Institute for Translational Genomics and Population Sciences, LA BioMed, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Chen CJ; Department of Ophthalmology, The University of Mississippi Medical Center, Jackson, MS., Chen YI; Institute for Translational Genomics and Population Sciences, LA BioMed, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Rotter JI; Institute for Translational Genomics and Population Sciences, LA BioMed, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Tsai FJ; School of Chinese Medicine, China Medical University, Taichung, Taiwan.; Departments of Medical Genetics, Pediatrics, and Medical Research, China Medical University Hospital, Tiachung, Tiawan., Hanis CL; Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX., Burdon KP; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Wong TY; Duke-NUS Medical School, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Cheng CY; Duke-NUS Medical School, National University of Singapore, Singapore chingyu.cheng@duke-nus.edu.sg.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	Diabetes [Diabetes] 2017 Dec; Vol. 66 (12), pp. 3130-3141. Date of Electronic Publication: 2017 Sep 26.
DOI:	10.2337/db17-0398
Abstrakt:	Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach. We pooled genome-wide association studies summary statistics from 18 studies for two DR phenotypes: any DR ( N = 2,969 case and 4,096 control subjects) and severe DR ( N = 1,277 case and 3,980 control subjects). Previously identified lipid-associated single nucleotide polymorphisms served as instrumental variables. Meta-analysis to combine the Mendelian randomization estimates from different cohorts was conducted. There was no statistically significant change in odds ratios of having any DR or severe DR for any of the lipid fractions in the primary analysis that used single nucleotide polymorphisms that did not have a pleiotropic effect on another lipid fraction. Similarly, there was no significant association in the Caucasian and Chinese subgroup analyses. This study did not show evidence of a causal role of the four lipid fractions on DR. However, the study had limited power to detect odds ratios less than 1.23 per SD in genetically induced increase in plasma lipid levels, thus we cannot exclude that causal relationships with more modest effect sizes exist. (© 2017 by the American Diabetes Association.)
Databáze:	MEDLINE
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