Maternal consumption of high-fat diet and grape juice modulates global histone H4 acetylation levels in offspring hippocampus: A preliminary study.

Autor: Gonçalves LK; Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: l.kneib@yahoo.com.br., da Silva IRV; Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: ivyreichert@gmail.com., Cechinel LR; Programa de Pós Graduação em Ciências Biológicas: Fisiologia, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: laurareck@gmail.com., Frusciante MR; Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: marina_frusciante@hotmail.com., de Mello AS; Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: melloas@gmail.com., Elsner VR; Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: elsner.viviane@gmail.com., Funchal C; Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: csfunchal@yahoo.com.br., Dani C; Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: carolinedani@yahoo.com.br.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2017 Nov 20; Vol. 661, pp. 29-32. Date of Electronic Publication: 2017 Sep 23.
DOI: 10.1016/j.neulet.2017.09.042
Abstrakt: This study aimed to investigate the impact of maternal consumption of a hyperlipid diet and grape juice on global histone H4 acetylation levels in the offsprinǵs hippocampus at different stages of development. During pregnancy and lactation of offspring, dams were divided into 4 groups: control diet (CD), high-fat diet (HFD), control diet and purple grape juice (PGJCD) and purple grape juice and high-fat diet (PGJHFD). Male Wistar rats were euthanized at 21days of age (PN21, adolescents) and at 50days of age (PN50, adults). The maternal consumption of grape juice increased global histone H4 acetylation levels in hippocampus of adolescents pups (PN21), an indicative of enhanced transcriptional activity and increased gene expression. On the other hand, the maternal high-fat diet diminished significantly this epigenetic marker in the adult phase (PN50), suggesting gene silencing. These preliminary findings demonstrated that the maternal choices are able to induce changes on histone H4 acetylation status in hippocampus of the offspring, which may modulate the expression of specific genes. Interestingly, this response occurs in an age and stimuli-dependent manner and strongly reinforce the importance of maternal choices during gestation.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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