Correlation among ocular surface disease, xerostomia, and nasal symptoms in patients with differentiated thyroid carcinoma subjected to radioiodine therapy: A prospective comparative study.

Autor: da Fonseca FL; Department of Ophthalmology, Medical School, University of São Paulo, São Paulo, Brazil., Yamanaka PK; Department of Ophthalmology, Medical School, University of São Paulo, São Paulo, Brazil., Mazoti L; Department of Otorhinolaryngology, Medical School, University of São Paulo, São Paulo, Brazil., Arakawa-Sugueno L; Department of Head and Neck Surgery, Medical School, University of São Paulo, São Paulo, Brazil., Kato JM; Department of Ophthalmology, Medical School, University of São Paulo, São Paulo, Brazil., Matayoshi S; Department of Ophthalmology, Medical School, University of São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2017 Dec; Vol. 39 (12), pp. 2381-2396. Date of Electronic Publication: 2017 Sep 25.
DOI: 10.1002/hed.24895
Abstrakt: Background: Some complications of radioiodine therapy have been reported, but the involvement of the eyes and adnexa is rarely discussed. The purpose of this study was to determine the correlation among ocular surface changes, xerostomia, and changes in the nasal mucosa associated with radioiodine therapy.
Methods: Patients subjected to radioiodine therapy (group 1) or not subjected (group 2) were prospectively evaluated by examinations of the ocular surface and tear film, saliva production, and nasal endoscopy. Ocular and nasal symptoms and xerostomia were evaluated using questionnaires.
Results: Evaluation of the ocular surface did not indicate significant differences between the groups. Nasal endoscopy revealed higher mucosal pallor in group 1 and worsening of the endoscopic appearance. Worsening of ocular symptoms and nasal symptoms, xerostomia, and a significant decrease in salivary production was also observed in group 1.
Conclusion: Subjective worsening of xerostomia, xerophthalmia, nasal symptoms, and changes in the nasal mucosa in group 1 was observed.
(© 2017 Wiley Periodicals, Inc.)
Databáze: MEDLINE
Externí odkaz: