NK cells produce high levels of IL-10 early after allogeneic stem cell transplantation and suppress development of acute GVHD.

Autor: Chan YLT; Institute of Immunology and Immunotherapy, University of Birmingham, UK., Zuo J; Institute of Immunology and Immunotherapy, University of Birmingham, UK., Inman C; Institute of Immunology and Immunotherapy, University of Birmingham, UK., Croft W; Institute of Immunology and Immunotherapy, University of Birmingham, UK.; Centre for Computational Biology, University of Birmingham, UK., Begum J; Institute of Immunology and Immunotherapy, University of Birmingham, UK., Croudace J; Institute of Immunology and Immunotherapy, University of Birmingham, UK., Kinsella F; Institute of Immunology and Immunotherapy, University of Birmingham, UK., Maggs L; Institute of Immunology and Immunotherapy, University of Birmingham, UK., Nagra S; Birmingham Health Partners, Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK., Nunnick J; Birmingham Health Partners, Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK., Abbotts B; Institute of Immunology and Immunotherapy, University of Birmingham, UK., Craddock C; Birmingham Health Partners, Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK., Malladi R; Birmingham Health Partners, Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK., Moss P; Institute of Immunology and Immunotherapy, University of Birmingham, UK.; Birmingham Health Partners, Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK.
Jazyk: angličtina
Zdroj: European journal of immunology [Eur J Immunol] 2018 Feb; Vol. 48 (2), pp. 316-329. Date of Electronic Publication: 2017 Oct 27.
DOI: 10.1002/eji.201747134
Abstrakt: Natural killer (NK) cells rapidly reconstitute following allogeneic stem cell transplantation (allo-SCT), at the time when alloreactive T cell immunity is being established. We investigated very early NK cell reconstitution in 82 patients following T cell-depleted allo-SCT. NK cell number rapidly increased, exceeding T cell reconstitution such that the NK:T cell ratio was over 40 by day 14. NK cells at day 14 (NK-14) were donor-derived, intensely proliferating and expressed chemokine receptors targeted to lymphoid and peripheral tissue. Spontaneous production of the immunoregulatory cytokine IL-10 was observed in over 70% of cells and transcription of cytokines and growth factors was augmented. NK-14 cell number was inversely correlated with the incidence of grade II-IV acute graft versus host disease (GVHD). These findings reveal that robust reconstitution of immunoregulatory NK cells by day 14 after allo-SCT is an important determinant of the clinical outcome, suggesting that NK cells may suppress the development of the T cell-mediated alloreactive immune response through production of IL-10.
(© 2017 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co.KGaA, Weinheim.)
Databáze: MEDLINE
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