Short-term respiratory effects of e-cigarettes in healthy individuals and smokers with asthma.

Autor: Lappas AS; 'George D. Behrakis Research Lab' Hellenic Cancer Society, Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Tzortzi AS; 'George D. Behrakis Research Lab' Hellenic Cancer Society, Athens, Greece.; Institute of Public Health, The American College of Greece, Athens, Greece., Konstantinidi EM; 'George D. Behrakis Research Lab' Hellenic Cancer Society, Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Teloniatis SI; 'George D. Behrakis Research Lab' Hellenic Cancer Society, Athens, Greece., Tzavara CK; Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Gennimata SA; Respiratory Function Laboratory, 1st Respiratory Medicine Department, Sotiria General Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Koulouris NG; Respiratory Function Laboratory, 1st Respiratory Medicine Department, Sotiria General Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Behrakis PK; 'George D. Behrakis Research Lab' Hellenic Cancer Society, Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece.; Institute of Public Health, The American College of Greece, Athens, Greece.
Jazyk: angličtina
Zdroj: Respirology (Carlton, Vic.) [Respirology] 2018 Mar; Vol. 23 (3), pp. 291-297. Date of Electronic Publication: 2017 Sep 24.
DOI: 10.1111/resp.13180
Abstrakt: Background and Objective: This study investigated the duration of immediate respiratory effects of e-cigarette smoking (ECS) and tested the hypothesis that ECS has more prominent effects in asthmatics compared with healthy smokers (HS).
Methods: Fifty-four smokers, 27 healthy (HS group) and 27 with intermittent asthma (mild asthma (MA) group) underwent a control session (no liquid, no resistor coil inside e-cigarette cartridge) and an experimental session of ECS using standardized puffing settings. Impulse oscillometry impedance (Z), resistance (R), reactance (X) and fractional exhaled nitric oxide (FeNO) were measured before and 0, 15 and 30 min after control and experimental sessions.
Results: Control session revealed no significant changes. In the experimental session, immediately post-ECS, both groups exhibited a significant increase in respiratory system total impedance at 5 Hz (Z5) (P < 0.001), respiratory system resistance at 5 Hz (R5) (P < 0.001), respiratory system resistance at 10 Hz (R10) (P < 0.001), respiratory system resistance at 20 Hz (R20) (P < 0.05), resonant frequency (P < 0.001) and reactance area (P < 0.05). MA exhibited higher baseline values and a more prominent effect immediately after ECS compared with HS for Z5 (P = 0.022), R5 (P = 0.010) and R10 (P = 0.013). FeNO decreased significantly in both groups (P < 0.001); HS returned to baseline values in ≤15 min while the MA maintained significantly lower values for an additional 15 min (P < 0.05) and returned to baseline values at 30 min post-ECS.
Conclusion: A single session of ECS had respiratory mechanical and inflammatory effects, which were more prominent in smokers with asthma.
(© 2017 Asian Pacific Society of Respirology.)
Databáze: MEDLINE
Externí odkaz: