Cytogenetic effects of Jacareubin from Calophyllum brasiliense on human peripheral blood mononucleated cells in vitro and on mouse polychromatic erythrocytes in vivo.
Autor: | García-Niño WR; Department of Toxicology, Centre for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Av. IPN 2508, San Pedro Zacatenco, GA Madero, Ciudad de México, CP 07360, Mexico., Estrada-Muñiz E; Department of Toxicology, Centre for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Av. IPN 2508, San Pedro Zacatenco, GA Madero, Ciudad de México, CP 07360, Mexico., Valverde M; Department of Genomic Medicine and Environmental Toxicology, Biomedical Research Institute, National University of Mexico (UNAM), Ciudad de México, CP 04510, Mexico., Reyes-Chilpa R; Department of Natural Products, Chemistry Institute, National University of Mexico (UNAM), Ciudad de México, CP 04510, Mexico., Vega L; Department of Toxicology, Centre for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Av. IPN 2508, San Pedro Zacatenco, GA Madero, Ciudad de México, CP 07360, Mexico. Electronic address: lvega@cinvestav.mx. |
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Jazyk: | angličtina |
Zdroj: | Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2017 Nov 15; Vol. 335, pp. 6-15. Date of Electronic Publication: 2017 Sep 22. |
DOI: | 10.1016/j.taap.2017.09.018 |
Abstrakt: | Jacareubin is a xanthone isolated from the heartwood of Calophyllum brasiliense with antibacterial and gastroprotective properties and the intention for clinical use as an anti-cancer treatment (due to the similar chemical structure to other anti-neoplastic drugs) requires an investigation of whether this compound can generate adverse effects on non-transformed cells. Jacareubin (0.5-1000μM in DMSO) was more cytotoxic on phytohemagglutinin (PHA)-stimulated normal human peripheral blood mononuclear cells (PBMCs; IC (Copyright © 2017 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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