Construct validity of pixel-by-pixel DCE-MRI: Correlation with conventional MRI scores in juvenile idiopathic arthritis.

Autor: Hemke R; Department of Radiology and Nuclear Medicine,Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. Electronic address: r.hemke@amc.nl., Nusman CM; Department of Radiology and Nuclear Medicine,Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands; Department of Pediatric Hematology, Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., van den Berg JM; Department of Pediatric Hematology, Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Lavini C; Department of Radiology and Nuclear Medicine,Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Schonenberg-Meinema D; Department of Pediatric Hematology, Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Dolman KM; Department of Pediatric Rheumatology, Reade, Dr. Jan van Breemenstraat 2, Amsterdam, The Netherlands; Department of Pediatric Rheumatology, St. Lucas Andreas Hospital, Jan Tooropstraat 164, Amsterdam, The Netherlands., Kuijpers TW; Department of Pediatric Hematology, Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Maas M; Department of Radiology and Nuclear Medicine,Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: European journal of radiology [Eur J Radiol] 2017 Sep; Vol. 94, pp. 1-5. Date of Electronic Publication: 2017 Jul 14.
DOI: 10.1016/j.ejrad.2017.07.003
Abstrakt: Objectives: To assess the capability of the pixel-by-pixel DCE-MRI time intensity curve (TIC)-shape analysis method in the evaluation of juvenile idiopathic arthritis (JIA) disease activity by correlating DCE-MRI parameters with semi-quantitative conventional-MRI scores of synovitis.
Methods: Clinical, laboratory, and (DCE)-MRI datasets of 85 JIA patients were prospectively obtained. TIC-shapes of each voxel were classified into one of seven predefined color-coded TIC shape categories. Spatial information on the relative amount of TIC-shapes, maximal enhancement (ME), maximal initial slope (MIS), initial area under the curve (iAUC), time-to-peak (TTP), enhancing volume (EV) was calculated of the synovial membrane. The grade of synovitis was scored on conventional MR images by two readers using the validated JAMRIS system. The Bonferroni method was used to correct for multiple testing, therefore, a P value of <0.0056 is considered significant (0.05/9=0.0056).
Results: The semi-quantitative JAMRIS synovitis score correlated substantially with the ME, EV, and iAUC (Rs=0.658, P<0.001; Rs=0.618, P<0.001; Rs=0.639, P<0.001), and moderately with MIS (Rs=0.453, P<0.001). A poor correlation was observed between the relative number of TIC-shapes 2-5 and the JAMRIS synovitis score (Rs=0.209, P=0.054; Rs=0.328, P=0.002; Rs=0.241, P=0.023; Rs=-0.241, P=0.026).
Conclusion: In this explorative study, both TIC shape and semi-quantitative DCE-MRI analysis methods showed moderate to substantial correlations with conventional MRI scores of disease activity, indicating that this methods are feasible. Further research is warranted whether DCE-MRI holds potential to become an objective and quantitative method for the evaluation of disease activity in JIA.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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