An atypical presentation of cardiac tamponade and periorbital swelling in a patient with eosinophilic granulomatosis with polyangiitis: a case report.

Autor: Keefe AC; Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Hymas JC; General Cardiology, St. Luke's Hospital, Twin Falls, ID, USA., Emerson LL; Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, UT, USA., Ryan JJ; Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA. john.ryan@hsc.utah.edu.; Division of Cardiovascular Medicine, University of Utah Health Science Center, 30 North 1900 East, Room 4A100, Salt Lake City, UT, 84132, USA. john.ryan@hsc.utah.edu.
Jazyk: angličtina
Zdroj: Journal of medical case reports [J Med Case Rep] 2017 Sep 24; Vol. 11 (1), pp. 271. Date of Electronic Publication: 2017 Sep 24.
DOI: 10.1186/s13256-017-1434-9
Abstrakt: Background: Eosinophilic granulomatosis with polyangiitis is a rare, necrotizing systemic vasculitis associated with asthma and hypereosinophilia. Its cause and pathophysiology are still being elucidated.
Case Presentation: We report a case of eosinophilic granulomatosis with polyangiitis in a 50-year-old Caucasian woman who presented with chest pain, dyspnea at rest, fever, and periorbital swelling. She was found to have significant hypereosinophilia and cardiac tamponade physiology. A biopsy confirmed extensive infiltration of both lungs and pericardium by eosinophils. She did not have any anti-neutrophil cytoplasmic antibodies.
Conclusions: Eosinophilic granulomatosis with polyangiitis diagnosis does not require the presence of anti-neutrophil cytoplasmic antibodies. Anti-neutrophil cytoplasmic antibody-positive and anti-neutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis may present with different clinical phenotypes, perhaps suggesting two distinct disease etiologies and distinct pathophysiology.
Databáze: MEDLINE
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