Nonspecific granulomatous prostatitis in association with eosinophilic epithelial metaplasia and prostatic adenocarcinoma.
| Autor: | Dikov DI; Department of Pathology, Jossigny Hospital, Jossigny, France., Koleva MS; Department of General and Clinical Pathology, Medical University - Plovdiv, Plovdiv, Bulgaria., Peshev ZK; Department of General and Clinical Pathology, Medical University - Plovdiv, Plovdiv, Bulgaria., Belovezhdov VT; Department of General and Clinical Pathology, Medical University - Plovdiv, Plovdiv, Bulgaria. |
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| Jazyk: | angličtina |
| Zdroj: | Indian journal of pathology & microbiology [Indian J Pathol Microbiol] 2017 Jul-Sep; Vol. 60 (3), pp. 409-411. |
| DOI: | 10.4103/IJPM.IJPM_130_16 |
| Abstrakt: | We present the first case of nonspecific granulomatous prostatitis (NSGP) associated with both eosinophilic epithelial metaplasia (EM) in benign glands and prostatic adenocarcinoma (PCa). The patient was a 68-year old man with a history of obstructive prostatic syndrome. After a transurethral resection of the prostate, the histologic analysis revealed NSGP and PCa. EM was seen in benign peri-granulomatous secretory epithelial cells as PAS Diastase positive granular eosinophilic transformation of the apical cell cytoplasm. This unusual cell appearance closely simulated the Paneth cell-like changes found in PCa. Negative chromogranin expression and weakly positive P504S immune staining in the foci of EM, surrounded by P63 positive basal cells confirmed the benign EM - phenotype. The combination of NSGP with both EM and PCa has not been reported in medical literature so far. Some observations concerning their differential diagnosis are suggested. |
| Databáze: | MEDLINE |
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