| Autor: |
Ahmad Rather M; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu 608002, India., Justin Thenmozhi A; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu 608002, India, justinthenmozhi@rediffmail.com., Manivasagam T; Department of Biochemistry and Biotechnology, Annamalai University, Annamalai nagar-608 002, Tamilnadu, India., Dhivya Bharathi M; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu 608002, India., Essa MM; Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman, Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman, Food and Brain Research Foundation, Chennai, Tamil Nadu 600094, India., Guillemin GJ; Neuroinflammation group, Faculty of Medicine and Health Sciences, Macquarie University, NSW, Australia. |
| Abstrakt: |
Alzheimer's disease (AD) is the most common form of dementia, characterized by memory loss, cognitive impairment and personality disorders accompanied by diffuse structural abnormalities in the brain of elderly people. The current investigation explored the neuroprotective potential of asiatic acid (AA), a natural triterpene of Centella asiatica on aluminium chloride (AlCl 3 ) induced rat model of AD. Oral administration of AlCl 3 (100 mg/kg b.w.) for 42 days significantly elevated the levels of Al, activity of acetyl cholinesterase and expressions of amyloid precursor protein, amyloid beta 1-42 , beta and gamma secretases, glial fibrillary acidic protein, ionized calcium binding adaptor molecule 1, interleukins -1β, 6, 4, 2, tumor necrosis factor alpha, inducible nitric oxide synthase, nuclear factor- k beta and cyclooxygenase-2 in the hippocampus and cortex compared to the control group. Our observations suggested that AA treatment mitigated AlCl 3 induced AD associated pathologies, which might be due to its multiple pharmacological actions. Further studies are necessary in order to explore the link between AlCl 3 -mediated oxidative stress and associated apoptosis to establish its neuroprotective role in AD. |
