| Autor: |
Orellana-Tavra C; Adsorption & Advanced Materials Laboratory (AAML), Department of Chemical Engineering and Biotechnology, University of Cambridge , Philippa Fawcett Drive, Cambridge CB3 0AS, U.K., Haddad S; Adsorption & Advanced Materials Laboratory (AAML), Department of Chemical Engineering and Biotechnology, University of Cambridge , Philippa Fawcett Drive, Cambridge CB3 0AS, U.K., Marshall RJ; WestCHEM School of Chemistry, University of Glasgow , Joseph Black Building, University Avenue, Glasgow G12 8QQ, U.K., Abánades Lázaro I; WestCHEM School of Chemistry, University of Glasgow , Joseph Black Building, University Avenue, Glasgow G12 8QQ, U.K., Boix G; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology , Campus UAB, Bellaterra, 08193 Barcelona, Spain., Imaz I; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology , Campus UAB, Bellaterra, 08193 Barcelona, Spain., Maspoch D; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology , Campus UAB, Bellaterra, 08193 Barcelona, Spain.; ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain., Forgan RS; WestCHEM School of Chemistry, University of Glasgow , Joseph Black Building, University Avenue, Glasgow G12 8QQ, U.K., Fairen-Jimenez D; Adsorption & Advanced Materials Laboratory (AAML), Department of Chemical Engineering and Biotechnology, University of Cambridge , Philippa Fawcett Drive, Cambridge CB3 0AS, U.K. |
| Abstrakt: |
A critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us to design an efficient drug delivery system. In particular, naphthalene-2,6-dicarboxylic acid and 4,4'-biphenyldicarboxylic acid ligands promote entry through the caveolin-pathway, allowing the particles to avoid lysosomal degradation and be delivered into the cytosol and enhancing their therapeutic activity when loaded with drugs. |
