| Autor: |
Sladek NE, Domeyer BE, Merriman RL, Brophy GT |
| Jazyk: |
angličtina |
| Zdroj: |
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 1978 Jul-Aug; Vol. 6 (4), pp. 412-7. |
| Abstrakt: |
Walker 256 rat carcinosarcoma cells growing as solid subcutaneous or intramuscular tumors depressed hepatic microsomal mixed-function oxygenase activity to less than 20% of control activity, but the same tumor cells growing as free ascites cells in the peritoneal cavity did not. Necrosis of the core area of solid tumors was observed. Tumor cells may release a substance that depresses hepatic microsomal mixed-function oxygenase activity only upon their death. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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