Correlation of radical-scavenging capacity and amoebicidal activity of Matricaria recutita L. (Asteraceae).

Autor: Hajaji S; Laboratoire de Parasitologie, Université de la Manouba, École Nationale de Médecine Vétérinaire de Sidi thabet, 2020, Tunisia; Faculté des sciences de Bizerte, Université de Carthage, 7021, Zarzouna, Tunisia. Electronic address: soumayahajjaji86@gmail.com., Sifaoui I; Laboratoire Matériaux-Molécules et Applications, IPEST, University of Carthage, La Marsa, Tunisia; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, La Laguna, Tenerife, Canary Islands, Spain., López-Arencibia A; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, La Laguna, Tenerife, Canary Islands, Spain., Reyes-Batlle M; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, La Laguna, Tenerife, Canary Islands, Spain., Jiménez IA; Instituto Universitario de Bio-Orgánica Antonio González, Department of Organic Chemistry, Universidad de La Laguna, Tenerife, Canary Islands, Spain., Bazzocchi IL; Instituto Universitario de Bio-Orgánica Antonio González, Department of Organic Chemistry, Universidad de La Laguna, Tenerife, Canary Islands, Spain., Valladares B; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, La Laguna, Tenerife, Canary Islands, Spain., Pinero JE; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, La Laguna, Tenerife, Canary Islands, Spain., Lorenzo-Morales J; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, La Laguna, Tenerife, Canary Islands, Spain., Akkari H; Laboratoire de Parasitologie, Université de la Manouba, École Nationale de Médecine Vétérinaire de Sidi thabet, 2020, Tunisia.
Jazyk: angličtina
Zdroj: Experimental parasitology [Exp Parasitol] 2017 Dec; Vol. 183, pp. 212-217. Date of Electronic Publication: 2017 Sep 14.
DOI: 10.1016/j.exppara.2017.09.011
Abstrakt: Some Acanthamoeba strains are able to cause Granulomatous Amoebic Encephalitis (GAE) and Acanthamoeba keratitis (AK) worldwide because of their pathogenicity. The treatment of Acanthamoeba infections is complicated due to the existence of a highly resistant cyst stage in their life cycle. Therefore, the elucidation of novel sources of anti-Acanthamoeba agents is an urgent need. In the present study, an evaluation of the antioxidant and anti-Acanthamoeba activity of compounds in flower extracts of Tunisian chamomile (Matricaria recutita L.) was carried out. Chamomile methanol extract was the most active showing an IC 50 of 66.235 ± 0.390 μg/ml, low toxicity levels when checked in murine macrophage toxicity model and presented also antioxidant properties. Moreover, a bio-guided fractionation of this extract was developed and led to the identification of a mixture of coumarins as the most active fraction. These results suggest a novel source of anti-Acanthamoeba compounds for the development of novel therapeutic agents against Acanthamoeba infections.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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