Susceptibility of colistin-resistant pathogens to predatory bacteria.

Autor: Dharani S; Department of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ 07103, USA. Electronic address: sonaldharani09@gmail.com., Kim DH; Department of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ 07103, USA. Electronic address: donghkim89@gmail.com., Shanks RMQ; Department of Ophthalmology, Charles T. Campbell Laboratory of Ophthalmic Microbiology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: shanksrm@upmc.edu., Doi Y; Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: yod4@pitt.edu., Kadouri DE; Department of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ 07103, USA. Electronic address: kadourde@sdm.rutgers.edu.
Jazyk: angličtina
Zdroj: Research in microbiology [Res Microbiol] 2018 Jan; Vol. 169 (1), pp. 52-55. Date of Electronic Publication: 2017 Sep 15.
DOI: 10.1016/j.resmic.2017.09.001
Abstrakt: The increase in multidrug-resistant Gram-negative bacterial infections has forced the reintroduction of antibiotics such as colistin. However, the spread of the plasmid-borne mcr-1 colistin resistance gene have moved us closer to an era of untreatable Gram-negative infections. To evaluate whether predatory bacteria could be used as a potential therapeutic to treat this upcoming threat, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on several clinically relevant mcr-1-positive, colistin-resistant isolates was evaluated. No change in the ability of the predators to prey on free swimming and biofilms of prey cells harboring mcr-1 was measured, as compared to their mcr-1 negative strain.
(Copyright © 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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