A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?

Autor: Abbott AM; Moffitt Cancer Center, Tampa, USA., Valente SA; The Cleveland Clinic, Cleveland, OH, USA., Loftus L; Moffitt Cancer Center, Tampa, USA., Tendulkar RD; The Cleveland Clinic, Cleveland, OH, USA., Greif JM; Alta Bates Summit Medical Center, Oakland, CA, USA., Bethke KP; Northwestern Medicine, Chicago, IL, USA., Donnelly ED; Northwestern Medicine, Chicago, IL, USA., Lottich C; Community Physician Network Breast Care, Community Health Network, Indianapolis, IN, USA., Ross DL; Community Physician Network Breast Care, Community Health Network, Indianapolis, IN, USA., Friedman NB; Mercy Medical Center, Baltimore, MD, USA., Bedi CG; Mercy Medical Center, Baltimore, MD, USA., Joh JE; Mercy Medical Center, Baltimore, MD, USA., Kelemen P; Ashikari Breast Center, Dobbs Ferry, NY, USA., Hoefer RA; The Sentara Dorothy G. Hoefer Comprehensive Breast Center, Newport News, VA, USA., Kang SK; The Sentara Dorothy G. Hoefer Comprehensive Breast Center, Newport News, VA, USA., Ruffer J; Advocate Good Shepherd Hospital, Barrington, IL, USA., Police A; University of California Irvine Medical Center, Irvine, CA, USA., Fyles A; Princess Margaret Cancer Centre, Toronto, ON, Canada., Graves GM; Sutter Cancer Center, Sacramento, CA, USA., Willey SC; MedStar Georgetown University Hospital, Washington, DC, USA., Tousimis EA; MedStar Georgetown University Hospital, Washington, DC, USA., Small W; Loyola University, Maywood, IL, USA., Lyons J; The Cleveland Clinic, Cleveland, OH, USA., Grobmyer S; The Cleveland Clinic, Cleveland, OH, USA., Laronga C; Moffitt Cancer Center, Tampa, USA. Electronic address: Christine.laronga@moffitt.org.
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2017 Oct; Vol. 214 (4), pp. 629-633. Date of Electronic Publication: 2017 Jun 23.
DOI: 10.1016/j.amjsurg.2017.06.018
Abstrakt: Background: Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited.
Methods: A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages <70 and ≥70.
Results: We evaluated 686 patients (<70 = 424; ≥70 = 262) who were margin and lymph node negative. Patients <70 were more likely to have longer operative time, oncoplastic closure, higher rates of IORT used as planned boost, and receive chemotherapy and post-operative WBRT. Wound complication rates were low and not significantly different between age groups. Median follow-up was 1.06 (range 0.51-1.9) years for < 70 and 1.01 (range 0.5-1.68) years for ≥ 70. There were 5 (0.73%) breast recurrences (4 in <70 and 1 ≥ 70, p = 0.65) and no axillary recurrences during follow-up.
Conclusions: IORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.
(Copyright © 2017. Published by Elsevier Inc.)
Databáze: MEDLINE
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