Vitamin K and its analogs: Potential avenues for prostate cancer management.

Autor:	Dasari S; Department of Biomedical Sciences, College of Medicine, University of Illinois, Rockford, IL, USA., Ali SM; Department of Biomedical Sciences, College of Medicine, University of Illinois, Rockford, IL, USA., Zheng G; Department of Biomedical Sciences, College of Medicine, University of Illinois, Rockford, IL, USA., Chen A; Department of Biomedical Sciences, College of Medicine, University of Illinois, Rockford, IL, USA., Dontaraju VS; Internal Medicine, Rockford Memorial Hospital, Rockford, IL, USA., Bosland MC; Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA., Kajdacsy-Balla A; Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA., Munirathinam G; Department of Biomedical Sciences, College of Medicine, University of Illinois, Rockford, IL, USA.
Jazyk:	angličtina
Zdroj:	Oncotarget [Oncotarget] 2017 May 19; Vol. 8 (34), pp. 57782-57799. Date of Electronic Publication: 2017 May 19 (Print Publication: 2017).
DOI:	10.18632/oncotarget.17997
Abstrakt:	Epidemiological studies have demonstrated a relationship between cancer incidence and dietary habits. Especially intake of certain essential nutrients like vitamins has been shown to be beneficial in experimental studies and some clinical trials. Vitamin K (VK) is an essential nutrient involved in the blood clotting cascade, and there are considerable experimental data demonstrating its potential anticancer activity in several cancer types including prostate cancer. Previous in vitro and in vivo studies have focused mainly on anti-oxidative effects as the underlying anticancer mechanism of VK. However, recent studies reveal that VK inhibits the growth of cancer cells through other mechanisms, including apoptosis, cell cycle arrest, autophagy, and modulation of various transcription factors such as Myc and Fos. In the present review, we focus on the anticancer effect of dietary VK and its analogs on prostate cancer, with an emphasis on the signaling pathways that are activated following exposure to these compounds. This review also highlights the potential of VK and its derivatives as an adjuvant treatment in combination with other vitamins or with chemotherapeutic drugs. Based on our recent results and a review of the existing literature, we present evidence that VK and its derivatives can potentially be explored as cancer therapy, especially for prostate cancer. Competing Interests: CONFLICTS OF INTEREST Authors declare that they do not have conflicts of interest.
Databáze:	MEDLINE
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