| Autor: |
Navasconi TR; Graduate Program in Health Sciences, Universidade Estadual de Maringá, Maringá, Brazil., Dos Reis VN; Graduate Program in Health Sciences, Universidade Estadual de Maringá, Maringá, Brazil., Freitas CF; Graduate Program in Chemistry, Universidade Estadual de Maringá, Maringá, Brazil., Pereira PCS; Graduate Program in Chemistry, Universidade Estadual de Maringá, Maringá, Brazil., Caetano W; Department of Chemistry, Universidade Estadual de Maringá, Maringá, Brazil., Hioka N; Department of Chemistry, Universidade Estadual de Maringá, Maringá, Brazil., Lonardoni MVC; Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Maringá, Brazil., Aristides SMA; Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Maringá, Brazil., Silveira TGV; Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Maringá, Brazil. |
| Abstrakt: |
Introduction: The treatment of cutaneous leishmaniasis (CL) is based primarily on the use of pentavalent antimonials, which may lead to many side effects limiting their use. Photodynamic therapy (PDT) is an alternative for the treatment of CL, and some xanthene dyes have the potential for use in PDT. Methods: The xanthenes rose bengal B (RB) and its derivatives rose bengal methyl ester (RBMET), and butyl ester (RBBUT) were analyzed for leishmanicidal activity against promastigotes and intracellular amastigotes of Leishmania amazonensis. Cytotoxicity was assessed in J774.A1 macrophages. Results: RB derivates RBMET (IC 50 9.83 μM), and RBBUT (IC 50 45.08 μM) showed leishmanicidal activity, however, were toxic to J774.A1 macrophages, resulting in low selectivity index. Conclusion: The RBMET and RBBUT showed to be effective against the L. amazonensis and the low selectivity index presented may not be a limitation for their use in PDT to CL treatment. |
