Subnuclear distribution of proteins: Links with genome architecture.

Autor: Shah FR; a Biotechnology, School of Biological Sciences , University of Kashmir , Srinagar , India., Bhat YA; a Biotechnology, School of Biological Sciences , University of Kashmir , Srinagar , India., Wani AH; a Biotechnology, School of Biological Sciences , University of Kashmir , Srinagar , India.
Jazyk: angličtina
Zdroj: Nucleus (Austin, Tex.) [Nucleus] 2018 Jan 01; Vol. 9 (1), pp. 42-55. Date of Electronic Publication: 2017 Sep 14.
DOI: 10.1080/19491034.2017.1361578
Abstrakt: Metazoan genomes have a hierarchal 3-dimensional (3D) organization scaling from nucleosomes, loops, topologically associating domains (TADs), compartments, to chromosome territories. The 3D organization of genome has been linked with development, differentiation and disease. However, the principles governing the 3D chromatin architecture are just beginning to get unraveled. The nucleus has very high concentration of proteins and these proteins are either diffusely distributed throughout the nucleus, or aggregated in the form of foci/bodies/clusters/speckles or in combination of both. Several evidences suggest that the distribution of proteins within the nuclear space is linked to the organization and function of genome. Here, we describe advances made in understanding the relationship between subnuclear distribution of proteins and genome architecture.
Databáze: MEDLINE
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