Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes.

Autor: Keser T; University of Zagreb Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, 10 000, Zagreb, Croatia., Gornik I; Clinical Hospital Centre Zagreb, Zagreb, Croatia., Vučković F; Genos Glycoscience Research Laboratory, Zagreb, Croatia., Selak N; University of Zagreb Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, 10 000, Zagreb, Croatia., Pavić T; University of Zagreb Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, 10 000, Zagreb, Croatia., Lukić E; Clinical Hospital Centre Zagreb, Zagreb, Croatia., Gudelj I; Genos Glycoscience Research Laboratory, Zagreb, Croatia., Gašparović H; Department of Cardiac Surgery, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia., Biočina B; Department of Cardiac Surgery, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia., Tilin T; Institute of Cardiovascular Science, University College London, London, UK., Wennerström A; National Institute for Health and Welfare (THL), Helsinki, Finland., Männistö S; National Institute for Health and Welfare (THL), Helsinki, Finland., Salomaa V; National Institute for Health and Welfare (THL), Helsinki, Finland., Havulinna A; National Institute for Health and Welfare (THL), Helsinki, Finland., Wang W; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.; Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China., Wilson JF; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Chaturvedi N; Institute of Cardiovascular Science, University College London, London, UK., Perola M; National Institute for Health and Welfare (THL), Helsinki, Finland., Campbell H; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Lauc G; University of Zagreb Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, 10 000, Zagreb, Croatia.; Genos Glycoscience Research Laboratory, Zagreb, Croatia., Gornik O; University of Zagreb Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, 10 000, Zagreb, Croatia. ogornik@pharma.hr.
Jazyk: angličtina
Zdroj: Diabetologia [Diabetologia] 2017 Dec; Vol. 60 (12), pp. 2352-2360. Date of Electronic Publication: 2017 Sep 13.
DOI: 10.1007/s00125-017-4426-9
Abstrakt: Aims/hypothesis: Better understanding of type 2 diabetes and its prevention is a pressing need. Changes in human plasma N-glycome are associated with many diseases and represent promising diagnostic and prognostic biomarkers. Variations in glucose metabolism directly affect glycosylation through the hexosamine pathway but studies of plasma glycome in type 2 diabetes are scarce. The aim of this study was to determine whether plasma protein N-glycome is changed in individuals who are at greater risk of developing type 2 diabetes.
Methods: Using a chromatographic approach, we analysed N-linked glycans from plasma proteins in two populations comprising individuals with registered hyperglycaemia during critical illness (increased risk for development of type 2 diabetes) and individuals who stayed normoglycaemic during the same condition: AcuteInflammation (59 cases vs 49 controls) and AcuteInflammation Replication (52 cases vs 14 controls) populations. N-glycome was also studied in individuals from FinRisk (37 incident cases of type 2 diabetes collected at baseline vs 37 controls), Orkney Complex Disease Study (ORCADES; 94 individuals with HbA 1c > 6.5% [47.5 mmol/mol] vs 658 controls) and Southall and Brent Revisited (SABRE) cohort studies (307 individuals with HbA 1c > 6.5% [47.5 mmol/mol] vs 307 controls).
Results: Individuals with increased risk for diabetes type 2 development (AcuteInflammation and AcuteInflammation Replication populations), incident cases of type 2 diabetes collected at baseline (FinRisk population) and individuals with elevated HbA 1c (ORCADES and SABRE populations) all presented with increased branching, galactosylation and sialylation of plasma protein N-glycans and these changes were of similar magnitude.
Conclusions/interpretation: Increased complexity of plasma N-glycan structures is associated with higher risk of developing type 2 diabetes and poorer regulation of blood glucose levels. Although further research is needed, this finding could offer a potential new approach for improvement in prevention of diabetes and its complications.
Databáze: MEDLINE
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