SJL bone marrow-derived macrophages do not have IRF3 mutations and are highly susceptible to Theiler's virus infection.

Autor: Son KN; Departments of Microbiology-Immunology, University of Illinois at Chicago, Chicago, IL, USA., Liang Z; Departments of Microbiology-Immunology, University of Illinois at Chicago, Chicago, IL, USA., Lipton HL; Departments of Microbiology-Immunology, University of Illinois at Chicago, Chicago, IL, USA; Departments of Neurology & Rehabilitation Medicine, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: hlipton@uic.edu.
Jazyk: angličtina
Zdroj: Virology [Virology] 2017 Dec; Vol. 512, pp. 21-24.
DOI: 10.1016/j.virol.2017.08.038
Abstrakt: It is well known that SJL mice are susceptible to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease while C57BL6 (B6) and B10 mice are resistant, and H-2 s on a B10 background (B10.S) contributes modestly to susceptibility. A recent study linked two IRF3 non-conservative mutations in SJL compared to B10.S mice to resistance to TMEV infection of SJL peritoneal-derived macrophages, an observation of practical interest in light of the central role of IRF3 transcription factor in the type I interferon (IFN) response. However, we did not find these non-conservative mutations among SJL, B10.S, B6 and B10 mice in the IRF3 amino acid sequence, and show SJL bone marrow-derived macrophages infected with TMEV exhibit increased virus RNA replication and infectious virus yields as well as greater IL-6 production than C57Bl strain (including B10.S) cultures.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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